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  • ISSN 1674-8301
  • CN 32-1810/R
Volume 33 Issue 5
Sep.  2019
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Ahn Changhwan, Kim Jae-Woo, Park Mi-Jin, Kim Seung Ryul, Lee Sung-Suk, Jeung Eui-Bae. Anti-inflammatory effects of natural volatile organic compounds from Pinus koraiensis and Larix kaempferi in mouse model[J]. The Journal of Biomedical Research, 2019, 33(5): 343-350. DOI: 10.7555/JBR.32.20180058
Citation: Ahn Changhwan, Kim Jae-Woo, Park Mi-Jin, Kim Seung Ryul, Lee Sung-Suk, Jeung Eui-Bae. Anti-inflammatory effects of natural volatile organic compounds from Pinus koraiensis and Larix kaempferi in mouse model[J]. The Journal of Biomedical Research, 2019, 33(5): 343-350. DOI: 10.7555/JBR.32.20180058
shu

Anti-inflammatory effects of natural volatile organic compounds from Pinus koraiensis and Larix kaempferi in mouse model

  • 1.

    Laboratory of Veterinary Biochemistry and Molecular Biology, Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea

  • 2.

    Division of Wood Chemistry & Microbiology, Department of Forest Products, National Institute of Forest Science, Seoul 02455, Republic of Korea

  • 3.

    Laboratory of Biochemistry, School of Medicine, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea

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  • Corresponding author:

    Eui-Bae Jeung, Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea. E-mail: ebjeung@chungbuk.ac.kr

  • Received Date: June 24, 2018
  • Revised Date: July 11, 2018
  • Accepted Date: July 31, 2018
  • Available Online: October 28, 2018
    Abstract
  • Natural volatile organic compounds (VOCs) extracted from conifers such as P. koraiensis and L. kaempferi have long been studied for their anti-oxidant, anti-proliferative, and anti-inflammatory effects. To evaluate the anti-inflammatory effects of VOCs from P. koraiensis and L. kaempferi, lipopolysaccharide (LPS) was administered to generate a mouse model for inflammation by the nasal route to the lungs and intraperitoneally to the whole body. VOCs of P. koraiensis and L. kaempferi were exposed to the mice by standardized wood panels with closed system. Increased levels of serum IgE and PGE2 were observed after exposure to dexamethasone and VOCs. We further determined the expression levels of inflammatory cytokine mRNA in the LPS-induced inflammation model by the reverse transcription quantitative polymerase chain reaction. Furthermore, the levels of cyclooxygenase-2, tumor necrosis factor-α, interleukin-1β, and interleukin-13 were determined in peripheral blood mononuclear cells. Those inflammatory cytokines and the key enzyme for inflammation cyclooxygenase-2 expression in PBMCs were strongly reversed by dexamethasone and VOCs. Lung tissues after nasal LPS exposure showed increased cytokine mRNA expressions which were suppressed by treatment with dexamethasone and VOCs. Furthermore, the damage induced by LPS was attenuated by dexamethasone and VOCs. In conclusion, the results from the present study indicate that VOCs of P. koraiensis and L. kaempferi have a therapeutic potential in the treatment or prevention of local and systemic inflammation due to their immunosuppressive effects.
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  • [1]
    Nagineni CN, Kutty RK, Detrick B, et al. Inflammatory cytokines induce intercellular adhesion molecule-1 (ICAM-1) mRNA synthesis and protein secretion by human retinal pigment epithelial cell cultures[J]. Cytokine, 1996, 8(8): 622–630.
    [2]
    Kawachi S, Jennings S, Panes J, et al. Cytokine and endothelial cell adhesion molecule expression in interleukin-10-deficient mice[J]. Am J Physiol Gastrointest Liver Physiol, 2000, 278(5): G734–G743.
    [3]
    Barnes PJ. Immunology of asthma and chronic obstructive pulmonary disease[J]. Nat Rev Immunol, 2008, 8(3): 183–192.
    [4]
    Beasley R, Roche WR, Roberts JA, et al. Cellular events in the bronchi in mild asthma and after bronchial provocation[J]. Am Rev Respir Dis, 1989, 139(3): 806–817.
    [5]
    Holgate S, Casale T, Wenzel S, et al. The anti-inflammatory effects of omalizumab confirm the central role of IgE in allergic inflammation[J]. J Allergy Clin Immunol, 2005, 115(3): 459–465.
    [6]
    Nakashima T, Hayashi T, Mizuno T. Regulation of the development of asthmatic inflammation by in situ CD4(+)Foxp3 (+) T cells in a mouse model of late allergic asthma[J]. Inflammation, 2014, 37(5): 1642–1653.
    [7]
    McConnell HM, Watts TH, Weis RM, et al. Supported planar membranes in studies of cell-cell recognition in the immune system[J]. Biochim Biophys Acta, 1986, 864(1): 95–106.
    [8]
    Galli SJ, Tsai M, Piliponsky AM. The development of allergic inflammation[J]. Nature, 2008, 454(7203): 445–454.
    [9]
    Zhang YB, Qin F, Sun HX. Immunosuppressive activity of Semen Persicae ethanol extract on specific antibody and cellular response to ovalbumin in mice[J]. Chem Biodivers, 2006, 3(9): 967–974.
    [10]
    Choi EM. Antinociceptive and antiinflammatory activities of pine (Pinus densiflora) pollen extract[J]. Phytother Res, 2007, 21(5): 471–475.
    [11]
    Ince I, Yesil-Celiktas O, Karabay-Yavasoglu NU, et al. Effects of Pinus brutia bark extract and Pycnogenol in a rat model of carrageenan induced inflammation[J]. Phytomedicine, 2009, 16(12): 1101–1104.
    [12]
    Yang H, Ahn C, Choi IG, et al. Estimation of the environmental effect of natural volatile organic compounds from Chamaecyparis obtusa and their effect on atopic dermatitis-like skin lesions in mice[J]. Mol Med Rep, 2015, 12(1): 345–350.
    [13]
    Joo SS, Yoo YM, Ko SH, et al. Effects of essential oil from Chamaecypris obtusa on the development of atopic dermatitis-like skin lesions and the suppression of Th cytokines[J]. J Dermatol Sci, 2010, 60(2): 122–125.
    [14]
    An BS, Kang JH, Yang H, et al. Anti-inflammatory effects of essential oils from Chamaecyparis obtusa via the cyclooxygenase-2 pathway in rats[J]. Mol Med Rep, 2013, 8(1): 255–259.
    [15]
    Yang H, Jung EM, Ahn C, et al. Elemol from Chamaecyparis obtusa ameliorates 2, 4-dinitrochlorobenzene-induced atopic dermatitis[J]. Int J Mol Med, 2015, 36(2): 463–472.
    [16]
    Almeida JR, Souza GR, Silva JC, et al. Borneol, a bicyclic monoterpene alcohol, reduces nociceptive behavior and inflammatory response in mice[J]. Sci Worl J, 2013, 2013: 808460.
    [17]
    Miguel MG. Antioxidant and anti-inflammatory activities of essential oils: a short review[J]. Molecules, 2010, 15(12): 9252–9287.
    [18]
    Rumchev K, Spickett J, Bulsara M, et al. Association of domestic exposure to volatile organic compounds with asthma in young children[J]. Thorax, 2004, 59(9): 746–751.
    [19]
    Boguniewicz M, Leung DY. Atopic dermatitis: a disease of altered skin barrier and immune dysregulation[J]. Immunol Rev, 2011, 242(1): 233–246.
    [20]
    Gebben HJ. Topical immunomodulators, such as tacrolimus and pimecrolimus, in the treatment of atopic dermatitis[J]. Ned Tijdschr Geneeskd, 2005, 149(32): 1816–1817.
    [21]
    Dharmage SC, Lowe AJ, Matheson MC, et al. Atopic dermatitis and the atopic march revisited[J]. Allergy, 2014, 69(1): 17–27. doi: 10.1111/all.12268
    [22]
    Abramovits W. Atopic dermatitis[J]. J Am Acad Dermatol, 2005, 53(1 Suppl 1): S86–S93.
    [23]
    Surh YJ, Na HK, Lee JY, et al. Molecular mechanisms underlying anti-tumor promoting activities of heat-processed Panax ginseng C.A. Meyer[J]. J Korean Med Sci, 2001, 16(Suppl): S38–S41.
    [24]
    Kawai M, Hirano T, Higa S, et al. Flavonoids and related compounds as anti-allergic substances[J]. Allergol Int, 2007, 56(2): 113–123.
    [25]
    Tan HY, Zhang AL, Chen D, et al. Chinese herbal medicine for atopic dermatitis: a systematic review[J]. J Am Acad Dermatol, 2013, 69(2): 295–304.
    [26]
    Jang HW, Ka MH, Lee KG. Antioxidant activity and characterization of volatile extracts of Capsicum annuum L. and Allium spp[J]. Flavour Fragrance J, 2008, 23: 178–184.
    [27]
    Wang W, Zhou Q, Liu L, et al. Anti-allergic activity of emodin on IgE-mediated activation in RBL-2H3 cells[J]. Pharmacol Rep, 2012, 64(5): 1216–1222.
    [28]
    Vender RB. Alternative treatments for atopic dermatitis: a selected review[J]. Skin Therapy Lett, 2002, 7(2): 1–5.
    [29]
    Park D, Jeon JH, Kwon SC, et al. Antioxidative activities of white rose flower extract and pharmaceutical advantages of its hexane fraction via free radical scavenging effects[J]. Biochem Cell Biol, 2009, 87(6): 943–952.
    [30]
    Navinés-Ferrer A, Serrano-Candelas E, Molina-Molina GJ, et al. IgE-related chronic diseases and anti-IgE-based treatments[J]. J Immunol Res, 2016, 2016: 8163803.
    [31]
    Heinzel FP, Sadick MD, Holaday BJ, et al. Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets[J]. J Exp Med, 1989, 169(1): 59–72.
    [32]
    Ricciotti E, FitzGerald GA. Prostaglandins and inflammation[J]. Arterioscler Thromb Vasc Biol, 2011, 31(5): 986–1000.
    [33]
    Oshiro Y, Morris DL. TNF-alpha release from human peripheral blood mononuclear cells to predict the proinflammatory activity of cytokines and growth factors[J]. J Pharmacol Toxicol Methods, 1997, 37(1): 55–59.
    [34]
    Lyss G, Knorre A, Schmidt TJ, et al. The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65[J]. J Biol Chem, 1998, 273(50): 33508–33516.
    [35]
    Paduch R, Kandefer-Szerszeń M, Trytek M, et al. Terpenes: substances useful in human healthcare[J]. Arch Immunol Ther Exp (Warsz), 2007, 55(5): 315–327.
    [36]
    Basholli-Salihu M, Schuster R, Hajdari A, et al. Phytochemical composition, anti-inflammatory activity and cytotoxic effects of essential oils from three Pinus spp[J]. Pharm Biol, 2017, 55(1): 1553–1560.
    [37]
    Coté H, Boucher MA, Pichette A, et al. Anti-inflammatory, antioxidant, antibiotic, and cytotoxic activities of tanacetum vulgare L. essential oil and its constituents[J]. Medicines (Basel), 2017, 4(2): pii: E34.
    [38]
    de Cássia da Silveira e Sá R, Andrade LN, de Sousa DP. A review on anti-inflammatory activity of monoterpenes[J]. Molecules, 2013, 18(1): 1227–1254.
    [39]
    Kim DS, Lee HJ, Jeon YD, et al. Alpha-pinene exhibits anti-inflammatory activity through the suppression of MAPKs and the NF-κB pathway in mouse peritoneal macrophages[J]. Am J Chin Med, 2015, 43(4): 731–742.
    [40]
    Li XJ, Yang YJ, Li YS, et al. α-Pinene, linalool, and 1-octanol contribute to the topical anti-inflammatory and analgesic activities of frankincense by inhibiting COX-2[J]. J Ethnopharmacol, 2016, 179: 22–26.
    [41]
    Zhong W, Cui Y, Yu Q, et al. Modulation of LPS-stimulated pulmonary inflammation by Borneol in murine acute lung injury model[J]. Inflammation, 2014, 37(4): 1148–1157.
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    Corresponding author: Jeung Eui-Bae, ebjeung@chungbuk.ac.kr
    • 1.

      Laboratory of Veterinary Biochemistry and Molecular Biology, Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea

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