Anti-inflammatory effects of natural volatile organic compounds from <i>Pinus koraiensis</i> and <i>Larix kaempferi</i> in mouse model

Ahn Changhwan; Kim Jae-Woo; Park Mi-Jin; Kim Seung Ryul; Lee Sung-Suk; Jeung Eui-Bae

doi:10.7555/JBR.32.20180058

Volume 33 Issue 5

Sep. 2019

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The Journal of Biomedical Research > 2019 > 33(5): 343-350. > DOI: 10.7555/JBR.32.20180058

Ahn Changhwan, Kim Jae-Woo, Park Mi-Jin, Kim Seung Ryul, Lee Sung-Suk, Jeung Eui-Bae. Anti-inflammatory effects of natural volatile organic compounds from Pinus koraiensis and Larix kaempferi in mouse model[J]. The Journal of Biomedical Research, 2019, 33(5): 343-350. DOI: 10.7555/JBR.32.20180058

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Anti-inflammatory effects of natural volatile organic compounds from Pinus koraiensis and Larix kaempferi in mouse model

1.
Laboratory of Veterinary Biochemistry and Molecular Biology, Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea
2.
Division of Wood Chemistry & Microbiology, Department of Forest Products, National Institute of Forest Science, Seoul 02455, Republic of Korea
3.
Laboratory of Biochemistry, School of Medicine, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea

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Corresponding author:
Eui-Bae Jeung, Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea. E-mail: ebjeung@chungbuk.ac.kr
Received Date: June 24, 2018
Revised Date: July 11, 2018
Accepted Date: July 31, 2018
Available Online: October 28, 2018

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Abstract

Abstract

Natural volatile organic compounds (VOCs) extracted from conifers such as P. koraiensis and L. kaempferi have long been studied for their anti-oxidant, anti-proliferative, and anti-inflammatory effects. To evaluate the anti-inflammatory effects of VOCs from P. koraiensis and L. kaempferi, lipopolysaccharide (LPS) was administered to generate a mouse model for inflammation by the nasal route to the lungs and intraperitoneally to the whole body. VOCs of P. koraiensis and L. kaempferi were exposed to the mice by standardized wood panels with closed system. Increased levels of serum IgE and PGE2 were observed after exposure to dexamethasone and VOCs. We further determined the expression levels of inflammatory cytokine mRNA in the LPS-induced inflammation model by the reverse transcription quantitative polymerase chain reaction. Furthermore, the levels of cyclooxygenase-2, tumor necrosis factor-α, interleukin-1β, and interleukin-13 were determined in peripheral blood mononuclear cells. Those inflammatory cytokines and the key enzyme for inflammation cyclooxygenase-2 expression in PBMCs were strongly reversed by dexamethasone and VOCs. Lung tissues after nasal LPS exposure showed increased cytokine mRNA expressions which were suppressed by treatment with dexamethasone and VOCs. Furthermore, the damage induced by LPS was attenuated by dexamethasone and VOCs. In conclusion, the results from the present study indicate that VOCs of P. koraiensis and L. kaempferi have a therapeutic potential in the treatment or prevention of local and systemic inflammation due to their immunosuppressive effects.
- Pinus koraiensis,
- Larix kaempferi,
- inflammation,
- cytokine,
- lungs

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Anti-inflammatory effects of natural volatile organic compounds from Pinus koraiensis and Larix kaempferi in mouse model