4.6

CiteScore

2.2

Impact Factor
  • ISSN 1674-8301
  • CN 32-1810/R
Xu Han, Hong Zhu. Hypothyroidism affects cholelithiasis causally: A two-sample bidirectional Mendelian randomization study[J]. The Journal of Biomedical Research. DOI: 10.7555/JBR.38.20240264
Citation: Xu Han, Hong Zhu. Hypothyroidism affects cholelithiasis causally: A two-sample bidirectional Mendelian randomization study[J]. The Journal of Biomedical Research. DOI: 10.7555/JBR.38.20240264

Unproofed Manuscript: The manuscript has been professionally copyedited and typeset to confirm the JBR’s formatting, but still needs proofreading by the corresponding author to ensure accuracy and correct any potential errors introduced during the editing process. It will be replaced by the online publication version.

Hypothyroidism affects cholelithiasis causally: A two-sample bidirectional Mendelian randomization study

More Information
  • Corresponding author:

    Hong Zhu. E-mail: zhuhong1059@126.com

  • Received Date: August 18, 2024
  • Revised Date: January 01, 2025
  • Accepted Date: January 06, 2025
  • CLC number: R581.2, Document code: B

    The authors reported no conflict of interests.

  • [1]
    Rassam Ghadhban B, Najim Abid F. The prevalence and correlation between subclinical hypothyroidism and gall stone disease in Baghdad teaching hospital[J]. Ann Med Surg (Lond), 2019, 37: 7–10. doi: 10.1016/j.amsu.2018.11.017
    [2]
    Laukkarinen J, Sand J, Nordback I. The underlying mechanisms: how hypothyroidism affects the formation of common bile duct stones-a review[J]. HPB Surg, 2012, 2012: 102825. https://pubmed.ncbi.nlm.nih.gov/23049165/
    [3]
    Li Y, Liu H, Ye S, et al. The effects of coagulation factors on the risk of endometriosis: a Mendelian randomization study[J]. BMC Med, 2023, 21(1): 195. doi: 10.1186/s12916-023-02881-z
    [4]
    Lawlor DA, Harbord RM, Sterne JAC, et al. Mendelian randomization: using genes as instruments for making causal inferences in epidemiology[J]. Stat Med, 2008, 27(8): 1133–1163. doi: 10.1002/sim.3034
    [5]
    Bowden J, Davey Smith G, Burgess S. Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression[J]. Int J Epidemiol, 2015, 44(2): 512–525. doi: 10.1093/ije/dyv080
    [6]
    Bowden J, Davey Smith G, Haycock PC, et al. Consistent estimation in mendelian randomization with some invalid instruments using a weighted median estimator[J]. Genet Epidemiol, 2016, 40(4): 304–314. doi: 10.1002/gepi.21965
    [7]
    Xu J, Zhang S, Tian Y, et al. Genetic causal association between iron status and osteoarthritis: a two-sample mendelian randomization[J]. Nutrients, 2022, 14(18): 3683. doi: 10.3390/nu14183683
    [8]
    Zhang D, Hu Y, Guo W, et al. Mendelian randomization study reveals a causal relationship between rheumatoid arthritis and risk for pre-eclampsia[J]. Front Immunol, 2022, 13: 1080980. doi: 10.3389/fimmu.2022.1080980
    [9]
    Kulkarni V, Ramteke H, Lamture Y, et al. A review of synchronous findings of hypothyroidism and cholelithiasis[J]. Cureus, 2022, 14(10): e30316. doi: 10.7759/CUREUS.30316
    [10]
    Wang Y, Yu X, Zhao QZ, et al. Thyroid dysfunction, either hyper or hypothyroidism, promotes gallstone formation by different mechanisms[J]. J Zhejiang Univ Sci B, 2016, 17(7): 515–525. doi: 10.1631/jzus.B1500210
    [11]
    Joshi AD, Andersson C, Buch S, et al. Four susceptibility loci for gallstone disease identified in a meta-analysis of genome-wide association studies[J]. Gastroenterology, 2016, 151(2): 351–363. e28.
    [12]
    Kube I, Zwanziger D. Thyroid dysfunction and cholesterol gallstone disease[J]. Exp Clin Endocrinol Diabetes, 2020, 128(6-7): 455–461. doi: 10.1055/a-1033-7273
    [13]
    Ravi PC, Thugu TR, Singh J, et al. Gallstone disease and its correlation with thyroid disorders: a narrative review[J]. Cureus, 2023, 15(9): e45116. doi: 10.7759/CUREUS.45116
    [14]
    Song Y, Xu C, Shao S, et al. Thyroid-stimulating hormone regulates hepatic bile acid homeostasis via SREBP-2/HNF-4α/CYP7A1 axis[J]. J Hepatol, 2015, 62(5): 1171–1179. doi: 10.1016/j.jhep.2014.12.006
    [15]
    Villm JA, DeMonaco SM, Panciera DL, et al. Evaluation of gallbladder motility assessed by ultrasonography in dogs with hyperlipidemia[J]. J Vet Intern Med, 2023, 37(3): 968–975. doi: 10.1111/jvim.16713
    [16]
    Laukkarinen J, Sand J, Aittomäki S, et al. Mechanism of the prorelaxing effect of thyroxine on the sphincter of Oddi[J]. Scand J Gastroenterol, 2002, 37(6): 667–673. doi: 10.1080/00365520212492
    [17]
    Kube I, Tardio LB, Hofmann U, et al. Hypothyroidism increases cholesterol gallstone prevalence in mice by elevated hydrophobicity of primary bile acids[J]. Thyroid, 2021, 31(6): 973–984. doi: 10.1089/thy.2020.0636
    [18]
    Morgan TH. Random segregation versus coupling in mendelian inheritance[J]. Science, 1911, 34(873): 384. doi: 10.1126/science.34.873.384
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