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  • ISSN 1674-8301
  • CN 32-1810/R
Hae Rim Lee, Bon-Sang Koo, Eun-Ok Jeon, Moo-Sung Han, Kyung-Cheol Min, Seung Baek Lee, Yeonji Bae, In-Pil Mo. Pathology and molecular characterization of recent Leucocytozoon caulleryi cases in layer flocks[J]. The Journal of Biomedical Research, 2016, 30(6): 517-524. DOI: 10.7555/JBR.30.2016K0017
Citation: Hae Rim Lee, Bon-Sang Koo, Eun-Ok Jeon, Moo-Sung Han, Kyung-Cheol Min, Seung Baek Lee, Yeonji Bae, In-Pil Mo. Pathology and molecular characterization of recent Leucocytozoon caulleryi cases in layer flocks[J]. The Journal of Biomedical Research, 2016, 30(6): 517-524. DOI: 10.7555/JBR.30.2016K0017

Pathology and molecular characterization of recent Leucocytozoon caulleryi cases in layer flocks

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We would like to thank the veterinarians involved for their cooperation and help in the sample collection. Funding for this research was provided by the project of National Institute of Environment Research (No. 2015080777).

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  • Received Date: May 01, 2016
  • Revised Date: June 16, 2016
  • Leucocytozoonosis was found in three layer farms in chickens with suspected fatty liver or fatty liver hemorrhagic syndrome in Korea between 2009 and 2011. These layer chicken flocks showed both mortality and decreased egg production for one or two weeks when they were between 59 and 82 weeks old. At the necropsy, the most prominent gross lesions were found in the liver, which was enlarged, had a fragile texture, exhibited yellowish discolorations, and had various hemorrhagic lesions. Tissue reactions associated with megaloschizonts specific for Leucocytozoon caulleryi were prominent upon microscopic examination of the liver without significant lipidosis. In addition, the ovaries and uterus were the most affected organs for Leucocytozoon caulleryi multiplication, which led to decreased egg productions. Molecular studies with formalin-fixed, paraffin-embedded tissues were performed in search of a partial region of the cytochrome b gene for hemosporidian parasites. Based on these results, the causal agent was determined to be closely related to Leucocytozoon caulleryi reported in Japan and Malaysia. In this study, we describe recently re-occurring leucocytozoonosis in layer chickens, which required histopathology for disease diagnosis. To prevent outbreaks and maintain chicken health and egg production, layer chickens need to be monitored for symptoms of leucocytozoonosis.
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    2. Elshahawy IS, Mohammed ES, Mawas AS, et al. First microscopic, pathological, epidemiological, and molecular investigation of Leucocytozoon (Apicomplexa: Haemosporida) parasites in Egyptian pigeons. Front Vet Sci, 2024, 11: 1434627. DOI:10.3389/fvets.2024.1434627
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    10. Pohuang T, Jittimanee S, Junnu S. Pathology and molecular characterization of Leucocytozoon caulleryi from backyard chickens in Khon Kaen Province, Thailand. Vet World, 2021, 14(10): 2634-2639. DOI:10.14202/vetworld.2021.2634-2639
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