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Volume 31 Issue 5
Aug.  2017
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Naureen Javeed, Debabrata Mukhopadhyay. Exosomes and their role in the micro-/macro-environment: a comprehensive review[J]. The Journal of Biomedical Research, 2017, 31(5): 386-394. DOI: 10.7555/JBR.30.20150162
Citation: Naureen Javeed, Debabrata Mukhopadhyay. Exosomes and their role in the micro-/macro-environment: a comprehensive review[J]. The Journal of Biomedical Research, 2017, 31(5): 386-394. DOI: 10.7555/JBR.30.20150162
shu

Exosomes and their role in the micro-/macro-environment: a comprehensive review

  • 1.

    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA

  • 2.

    Department of Biochemistry and Molecular Biology, Mayo Clinic, Jacksonville, FL 32224, USA

Funds: 

This work was partly supported by Florida Department of Health Cancer Research Chair Funding, NIH fund-ing (CA150190, HL 70567 and CA78383, and Mayo Clinic Pancreatic Cancer SPORE P50 CA102701 Pilot Project) to DM and NCI training grant 1T32 CA148073 (to DM) Pre-doctoral fellowship to NJ.

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  • Received Date: November 28, 2015
  • Revised Date: December 14, 2015
    Graphical Abstract
    • Abstract
  • The importance of extracellular vesicles (EVs) in cell-cell communication has long been recognized due to their ability to transfer important cellular cargoes such as DNA, mRNA, miRNAs, and proteins to target cells. Compelling evidence supports the role of EVs in the horizontal transfer of cellular material which has the potential to influence normal cellular physiology and promote various disease states. Of the different types of EVs, exosomes have garnered much attention in the past decade due to their abundance in various biological fluids and ability to affect multiple organ systems. The main focus of this review will be on cancer and how cancer-derived exosomes are important mediators of metastasis, angiogenesis, immune modulation, and the tumor macro-/microenvironment. We will also discuss exosomes as potential biomarkers for cancers due to their abundance in biological fluids, ease of uptake, and cellular content. Exosome use in diagnosis, prognosis, and in establishing treatment regimens has enormous potential to revolutionize patient care.
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