Naureen Javeed, Debabrata Mukhopadhyay. Exosomes and their role in the micro-/macro-environment: a
comprehensive review[J]. The Journal of Biomedical Research, 2017, 31(5): 386-394. DOI: 10.7555/JBR.30.20150162
Citation:
Naureen Javeed, Debabrata Mukhopadhyay. Exosomes and their role in the micro-/macro-environment: a
comprehensive review[J]. The Journal of Biomedical Research, 2017, 31(5): 386-394. DOI: 10.7555/JBR.30.20150162
Naureen Javeed, Debabrata Mukhopadhyay. Exosomes and their role in the micro-/macro-environment: a
comprehensive review[J]. The Journal of Biomedical Research, 2017, 31(5): 386-394. DOI: 10.7555/JBR.30.20150162
Citation:
Naureen Javeed, Debabrata Mukhopadhyay. Exosomes and their role in the micro-/macro-environment: a
comprehensive review[J]. The Journal of Biomedical Research, 2017, 31(5): 386-394. DOI: 10.7555/JBR.30.20150162
Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA
2.
Department of Biochemistry and Molecular Biology, Mayo Clinic, Jacksonville, FL 32224, USA
Funds:
This work was partly supported by Florida Department of Health Cancer Research Chair Funding, NIH
fund-ing (CA150190, HL 70567 and CA78383, and
Mayo Clinic Pancreatic Cancer SPORE P50 CA102701
Pilot Project) to DM and NCI training grant 1T32
CA148073 (to DM) Pre-doctoral fellowship to NJ.
The importance of extracellular vesicles (EVs) in cell-cell communication has long been recognized due to their
ability to transfer important cellular cargoes such as DNA, mRNA, miRNAs, and proteins to target cells. Compelling
evidence supports the role of EVs in the horizontal transfer of cellular material which has the potential to influence
normal cellular physiology and promote various disease states. Of the different types of EVs, exosomes have garnered
much attention in the past decade due to their abundance in various biological fluids and ability to affect multiple
organ systems. The main focus of this review will be on cancer and how cancer-derived exosomes are important
mediators of metastasis, angiogenesis, immune modulation, and the tumor macro-/microenvironment. We will also
discuss exosomes as potential biomarkers for cancers due to their abundance in biological fluids, ease of uptake, and
cellular content. Exosome use in diagnosis, prognosis, and in establishing treatment regimens has enormous potential
to revolutionize patient care.