4.6

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  • ISSN 1674-8301
  • CN 32-1810/R
Qiu Sheng, Jun Yang, Qiaoling Zhao, Fen Li. Dynamic monitoring of menopause hormone therapy and defining the cut-off value of endometrial thickness during uterine bleeding[J]. The Journal of Biomedical Research, 2016, 30(3): 191-196. DOI: 10.7555/JBR.30.20150147
Citation: Qiu Sheng, Jun Yang, Qiaoling Zhao, Fen Li. Dynamic monitoring of menopause hormone therapy and defining the cut-off value of endometrial thickness during uterine bleeding[J]. The Journal of Biomedical Research, 2016, 30(3): 191-196. DOI: 10.7555/JBR.30.20150147

Dynamic monitoring of menopause hormone therapy and defining the cut-off value of endometrial thickness during uterine bleeding

Funds: 

the Sci-tech Research Development Program of Shaanxi Province (No. 2015SF015)

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  • Received Date: October 21, 2015
  • Revised Date: December 11, 2015
  • The aim of this study was to evaluate the effects of low-dose tibolone therapy on ovarian area, uterine volume and endometrial thickness, and define the cut-off value of endometrial thickness for curettage during uterine bleeding. We followed 619 postmenopausal women, aged 40-60 years, for two years. There were 301 subjects in the low-dose tibolone treatment group and 318 subjects in the control group. The ovarian area, uterine volume and endometrial thickness in all participants were measured by transvaginal ultrasound prior to, one and two years post enrollment, respectively. Endometrial specimens were collected from all subjects with abnormal uterine bleeding during the follow-up period. We found that the uterine volume in the treatment group was greater than that in the control group, and the difference was significant (P<0.05), but there were no significant differences in ovarian area and endometrial thickness between the two groups (P>0.05). When the cut-off value for endometrial thickness was 7.35 mm, the sensitivity and specificity were 100% and 79.07%, respectively, and 85.71% and 93.02% when 7.55 mm was set as the cut-off during tibolone therapy. The results indicate that low-dose tibolone therapy may postpone uterine atrophy and the cut-off value of endometrial thickness may be appropriately adjusted for curettage.
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