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  • ISSN 1674-8301
  • CN 32-1810/R
Volume 30 Issue 3
Apr.  2016
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Chun Yuan, Xiaoqiang Liu, Yundong Mao, Feiyang Diao, Yugui Cui, Jiayin Liu. Polycystic ovary syndrome patients with high BMI tend to have functional disorders of androgen excess: a prospective study[J]. The Journal of Biomedical Research, 2016, 30(3): 197-202. DOI: 10.7555/JBR.30.20140111
Citation: Chun Yuan, Xiaoqiang Liu, Yundong Mao, Feiyang Diao, Yugui Cui, Jiayin Liu. Polycystic ovary syndrome patients with high BMI tend to have functional disorders of androgen excess: a prospective study[J]. The Journal of Biomedical Research, 2016, 30(3): 197-202. DOI: 10.7555/JBR.30.20140111
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Polycystic ovary syndrome patients with high BMI tend to have functional disorders of androgen excess: a prospective study

  • The State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210036, China

Funds: 

The Major State Basic Research Development Program of China (973 Program: No. 2012CB944902 and No. 2012CB944703), the National Natural Science Foundation of China (No. 30801236), and the PriorityAcademic Program Development of Jiangsu HigherEducation Institutions

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  • Received Date: June 22, 2014
  • Revised Date: September 02, 2014
    Graphical Abstract
    • Abstract
  • Biochemical or clinical changes of hyperandrogenism are important elements of polycystic ovary syndrome (PCOS). There is currently no consensus on the definition and diagnostic criteria of hyperandrogenism in PCOS. The aim of this study was to investigate the complex symptoms of hyperandrogenic disorders and the correlations between metabolism and hyperandrogenism in patients with PCOS from an outpatient reproductive medicine clinic in China. We conducted a case control study of 125 PCOS patients and 130 controls to evaluate differences in body mass index (BMI), total testosterone (TT), modified Ferriman–Gallwey hirsutism score, sex hormone binding globulin (SHBG), homeostasis model assessment-estimated insulin resistance (HOMA-IR) and free androgen index (FAI) between PCOS patients and controls and subgroups of PCOS. The prevalence of acne and hirsutism did not differ significantly between the hyperandrogenic and non-hyperandrogenic subgroup. Patients with signs of hyperandrogenism had significantly higher BMI (P < 0.05), but differences in TT, SHBG, FAI and waist/hip ratio were insignificant. The odds ratio of overweight was calculated for all PCOS patients. Our results suggest that PCOS patients with high BMI tend to have functional disorders of androgen excess; therefore, BMI may be a strong predictor of hyperandrogenism in PCOS.
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    1. Mansour A, Noori M, Hakemi MS, et al. Hyperandrogenism and anthropometric parameters in women with polycystic ovary syndrome. BMC Endocr Disord, 2024, 24(1): 201. DOI:10.1186/s12902-024-01733-y
    2. Patel A, Saraf A, Rao VA, et al. Comparing Assisted Reproductive Outcomes in Women with Different Polycystic Ovary Syndrome Phenotypes Undergoing Frozen Embryo Transfer. J Hum Reprod Sci, 2023, 16(4): 340-345. DOI:10.4103/jhrs.jhrs_145_23
    3. Ji H, Su Y, Zhang M, et al. Functional Ovarian Cysts in Artificial Frozen-Thawed Embryo Transfer Cycles With Depot Gonadotropin-Releasing Hormone Agonist. Front Endocrinol (Lausanne), 2022, 13: 828993. DOI:10.3389/fendo.2022.828993
    4. Kałużna M, Czlapka-Matyasik M, Kompf P, et al. Lipid ratios and obesity indices are effective predictors of metabolic syndrome in women with polycystic ovary syndrome. Ther Adv Endocrinol Metab, 2022, 13: 20420188211066699. DOI:10.1177/20420188211066699
    5. Bakhashab S, Batarfi AA, Filimban N, et al. Polycystic ovary syndrome is linked with the fat mass obesity (FTO) gene variants rs17817449 and rs1421085 in western Saudi Arabia. Bioinformation, 2021, 17(11): 904-910. DOI:10.6026/97320630017904
    6. Deepika V, Preethy P. Evaluation of Body Fat Composition and Digit Ratio (2D:4D) in Polycystic Ovary Syndrome in Adolescents. Curr Health Sci J, 2021, 47(3): 433-437. DOI:10.12865/CHSJ.47.03.15
    7. Cao CH, Wei Y, Liu R, et al. Three-Dimensional Genome Interactions Identify Potential Adipocyte Metabolism-Associated Gene STON1 and Immune-Correlated Gene FSHR at the rs13405728 Locus in Polycystic Ovary Syndrome. Front Endocrinol (Lausanne), 2021, 12: 686054. DOI:10.3389/fendo.2021.686054
    8. Jain T, Negris O, Brown D, et al. Characterization of polycystic ovary syndrome among Flo app users around the world. Reprod Biol Endocrinol, 2021, 19(1): 36. DOI:10.1186/s12958-021-00719-y
    9. Saadia Z. Follicle Stimulating Hormone (LH: FSH) Ratio in Polycystic Ovary Syndrome (PCOS) - Obese vs. Non- Obese Women. Med Arch, 2020, 74(4): 289-293. DOI:10.5455/medarh.2020.74.289-293
    10. Huang L, Lu Q, Du J, et al. Cumulative live birth rates of in vitro fertilization/intracytoplasmic sperm injection after multiple complete cycles in China. J Biomed Res, 2020, 34(5): 361-368. DOI:10.7555/JBR.34.20200035
    11. Mesinovic J, Teede HJ, Shorakae S, et al. The Relationship between Vitamin D Metabolites and Androgens in Women with Polycystic Ovary Syndrome. Nutrients, 2020, 12(5): 1219. DOI:10.3390/nu12051219
    12. Sachdeva G, Gainder S, Suri V, et al. Obese and Non-obese Polycystic Ovarian Syndrome: Comparison of Clinical, Metabolic, Hormonal Parameters, and their Differential Response to Clomiphene. Indian J Endocrinol Metab, 2019, 23(2): 257-262. DOI:10.4103/ijem.IJEM_637_18
    13. Wang C, Xu Y. Mechanisms for Sex Differences in Energy Homeostasis. J Mol Endocrinol, 2019, 62(2): R129-R143. DOI:10.1530/JME-18-0165
    14. Wang YY, Li SW, Luo S, et al. How to Evaluate Acne in Reproductive-Age Women: An Epidemiological Study in Chinese Communities. Biomed Res Int, 2019, 2019: 6126808. DOI:10.1155/2019/6126808
    15. Li A, Zhang L, Jiang J, et al. Follicular hyperandrogenism and insulin resistance in polycystic ovary syndrome patients with normal circulating testosterone levels. J Biomed Res, 2017, 32(3): 208-14. DOI:10.7555/JBR.32.20170136. Online ahead of print
    16. Afifi L, Saeed L, Pasch LA, et al. Association of ethnicity, Fitzpatrick skin type, and hirsutism: A retrospective cross-sectional study of women with polycystic ovarian syndrome. Int J Womens Dermatol, 2017, 3(1): 37-43. DOI:10.1016/j.ijwd.2017.01.006

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