Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
2.
Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210030, China
3.
Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210031, China
4.
Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210032, China
5.
Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210033, China
6.
Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210034, China
7.
Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210035, China
8.
Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210036, China
9.
Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210037, China
10.
Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210038, China
11.
Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210039, China
12.
Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210040, China
Funds:
This study was support by grants from the National Key Technologies R&D Program of China during the 11th Five-Year Plan Period (2007BAI07A10), the Jiangsu Province Science and Technology Support Program (BE2009613), the 9th Six Talents Peak Project of Jiangsu Province (WS-022), and the Qing Lan Project.
The purpose of this study was to assess the relationship between arterial stiffness, as measured by brachial-ankle pulse wave velocity (baPWV), and the presence of the metabolic syndrome (MS) in a Chinese population. A total of 4,445 subjects were enrolled. The prevalence of MS in our study population was 21.7%, 17.2% and 25.6% for the general population, males and females, respectively. With adjustments for age, gender, cigarette smoking, heart rate, total cholesterol, low-density lipoprotein (LDL) cholesterol, and the use of anti-hypertensive drug, the stepwise regression analysis showed that baPWV had a significant relationship with components of MS, including systolic blood pressure (P , 0.001), diastolic blood pressure (P , 0.001), glucose (P , 0.001), highdensity lipoprotein (HDL) cholesterol (P 5 0.04), and triglycerides (P , 0.001), but no relationship with waist circumference (P 5 0.25). With an increase in the number of the MS components, baPWV increased significantly both in women and men. This study indicated that the MS is indeed a risk factor for arterial stiffness. Monitoring of baPWV in patients with MS may help in identifying persons at high risk for cardiovascular disease.
Authors and Reviewers
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