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  • ISSN 1674-8301
  • CN 32-1810/R
Volume 25 Issue 4
Jun.  2011
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Xi Li, Tingzhong Wang, Ke Han, Xiaozhen Zhuo, Qun Lu, Aiqun Ma. Bisoprolol reverses down-regulation of potassium channel proteins in ventricular tissues of rabbits with heart failure[J]. The Journal of Biomedical Research, 2011, 25(4): 274-279. DOI: 10.1016/S1674-8301(11)60037-7
Citation: Xi Li, Tingzhong Wang, Ke Han, Xiaozhen Zhuo, Qun Lu, Aiqun Ma. Bisoprolol reverses down-regulation of potassium channel proteins in ventricular tissues of rabbits with heart failure[J]. The Journal of Biomedical Research, 2011, 25(4): 274-279. DOI: 10.1016/S1674-8301(11)60037-7
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Bisoprolol reverses down-regulation of potassium channel proteins in ventricular tissues of rabbits with heart failure

  • Department of Cardiovascular Medicine, the First Affiliated Hospital of Medical School, Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China/Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi’an, Shaanxi 710061, China/Key Laboratory of Envi

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This work was supported by the State Key Program of the National Natural Science Foundation of China (No. 30830051).

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    • Abstract
  • Remodeling of ion channels is an important mechanism of arrhythmia induced by heart failure (HF). We in-vestigated the expression of potassium channel encoding genes in the ventricles of rabbit established by volume-overload operation followed with pressure-overload. The reversible effect of these changes with bisoprolol was also evaluated. The HF group exhibited left ventricular enlargement, systolic dysfunction, prolongation of cor-rected QT interval (QTc), and increased plasma brain natriuretic peptide levels in the HF rabbits. Several potas-sium channel subunit encoding genes were consistently down-regulated in the HF rabbits. After bisoprolol treat-ment, heart function was improved significantly and QTc was shortened. Additionally, the mRNA expression of potassium channel subunit genes could be partially reversed. The down-regulated expression of potassium channel subunits Kv4.3, Kv1.4, KvLQT1, minK and Kir 2.1 may contribute to the prolongation of action potential duration in the heart of rabbits induced by volume combined with pressure overload HF. Bisoprolol could partially reverse these down-regulations and improve heart function.
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