Figures of the Article

• Identification of a novel long non-coding RNA (lncRNA) implicated in hepatic lipid metabolism.
• Characterization of the non-coding property and sub-cellular location of lnc_217.
• Knockdown of lnc_217 reduced hepatic lipid accumulation and hyperlidiaemai in high-fat diet fed (HFD) mice.
• Liver-specific knockdown of lnc_217 decreased hepatic lipogenesis and increased fatty acid β-oxiation in mice.
• Knockdown of lnc_217 decreased lipogenesis and increased fatty acid β-oxidation in primary hepatocytes.
• Overexpression of lnc_217 increased lipogenesis and decreased fatty acid β-oxidation in Hepa1-6 cells.