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  • ISSN 1674-8301
  • CN 32-1810/R
Volume 30 Issue 5
Aug.  2016
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Henry Liu, Lisa Sangkum, Geoffrey Liu, Michael Green, Marilyn Li, Alan Kaye. Effects of epinephrine on angiogenesis-related gene expressions in cultured rat cardiomyocytes[J]. The Journal of Biomedical Research, 2016, 30(5): 380-385. DOI: 10.7555/JBR.30.20160024
Citation: Henry Liu, Lisa Sangkum, Geoffrey Liu, Michael Green, Marilyn Li, Alan Kaye. Effects of epinephrine on angiogenesis-related gene expressions in cultured rat cardiomyocytes[J]. The Journal of Biomedical Research, 2016, 30(5): 380-385. DOI: 10.7555/JBR.30.20160024
shu

Effects of epinephrine on angiogenesis-related gene expressions in cultured rat cardiomyocytes

  • 1.

    Department of Anesthesiology & Perioperative Medicine, Drexel University College of Medicine, Hahnemann University Hospital, Philadelphia, PA 19102, USA

  • 2.

    Division of Genomic Diagnostics, Dept. of Pathology & Laboratory Medicine, Children’s Hospital of Philadelphia, Perelman School of Medicine University of Pennsylvania, Philadelphia, PA 19104, USA

  • 3.

    Department of Anesthesiology, LSUHSC-New Orleans, New Orleans, LA 70112, USA

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internal funding from the Department of Anesthesiology and Perioperative Medicine

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  • Received Date: February 15, 2016
  • Revised Date: March 17, 2016
    Graphical Abstract
    • Abstract
  • Epinephrine is often used for the treatment of patients with heart failure, low cardiac output and cardiac arrest. It can acutely improve hemodynamic parameters; however, it does not seem to improve longer term clinical outcomes. Therefore, we hypothesized that epinephrine may induce unfavorable changes in gene expression of cardiomyocyte. Thus, we investigated effects of epinephrine exposure on the mediation or modulation of gene expression of cultured cardiomyocytes at a genome-wide scale. Our investigation revealed that exposure of cardiomyocytes to epinephrine in an in vitro environment can up-regulate the expression of angiopoietin-2 gene (+ 2.1 times), and down-regulate the gene expression of neuregulin 1 ( – 3.7 times), plasminogen activator inhibitor-1 ( – 2.4 times) and SPARC-related modular calcium-binding protein-2 ( – 4.5 times). These changes suggest that epinephrine exposure may induce inhibition of angiogenesis-related gene expressions in cultured rat cardiomyocytes. The precise clinical significance of these changes in gene expression, which was induced by epinephrine exposure, warrants further experimental and clinical investigations.
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    1. Venakatesh AG, Mathew JJ, Coleman S, et al. Effects of milrinone on inflammatory response-related gene expressions in cultured rat cardiomyocytes. J Biomed Res, 2018, 33(4): 258-63. DOI:10.7555/JBR.32.20170085. Online ahead of print
    2. Chen S, Liu GL, Li MM, et al. Effects of Epinephrine on Inflammation-Related Gene Expressions in Cultured Rat Cardiomyocytes. Transl Perioper Pain Med, 2017, 2(1): 13-19.

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