3.5

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2.3

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  • ISSN 1674-8301
  • CN 32-1810/R
Hui Bai, Nan Li, Xiaodan Zhou, Chenchen Wang, Yan Zhang, Xudong Zhu, Min Huang, Yaoyu Chen, Xiaoyu Li, Qing Yang, Chaojun Li, Jingjing Ben, Qi Chen. GRP78 inhibits macrophage adhesion via SR-A[J]. The Journal of Biomedical Research, 2014, 28(4): 269-274. DOI: 10.7555/JBR.28.20130054
Citation: Hui Bai, Nan Li, Xiaodan Zhou, Chenchen Wang, Yan Zhang, Xudong Zhu, Min Huang, Yaoyu Chen, Xiaoyu Li, Qing Yang, Chaojun Li, Jingjing Ben, Qi Chen. GRP78 inhibits macrophage adhesion via SR-A[J]. The Journal of Biomedical Research, 2014, 28(4): 269-274. DOI: 10.7555/JBR.28.20130054
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GRP78 inhibits macrophage adhesion via SR-A

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    • Abstract
  • Class A scavenger receptor (SR-A) plays an important role in macrophage adhesion. However, the underlying mechanism remains unclear. We previously found that 78 kDa glucose-regulated protein (GRP78) inhibited SRA- mediated ligand internalization into macrophage by binding to SR-A. The aim of the study was to investigate whether GRP78 could regulate SR-A-mediated cell adhesion. We demonstrated that GRP78 bound directly to SR-A by fluorescence resonance energy transfer (FRET) assay. Overexpression of GRP78 inhibited macrophage adhesion via SR-A. These results suggest that GRP78 may act as an inhibitor of macrophage adhesion via SR-A.
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