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  • ISSN 1674-8301
  • CN 32-1810/R
Volume 26 Issue 5
Aug.  2012
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Yao Liu, Qin Zhang, Chuanli Ren, Yanbing Ding, Guangfu Jin, Zhibin Hu, Yaochu Xu, Hongbing Shen. A germline variant N375S in MET and gastric cancer susceptibility in a Chinese population[J]. The Journal of Biomedical Research, 2012, 26(5): 315-318. DOI: 10.7555/JBR.26.20110087
Citation: Yao Liu, Qin Zhang, Chuanli Ren, Yanbing Ding, Guangfu Jin, Zhibin Hu, Yaochu Xu, Hongbing Shen. A germline variant N375S in MET and gastric cancer susceptibility in a Chinese population[J]. The Journal of Biomedical Research, 2012, 26(5): 315-318. DOI: 10.7555/JBR.26.20110087
shu

A germline variant N375S in MET and gastric cancer susceptibility in a Chinese population

  • 1.

    Department of Epidemiology and Biostatistics, MOE Key Laboratory of Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 210029, China

  • 2.

    Medical Laboratory, Northern Jiangsu People’s Hospital, Yangzhou, Jiangsu 225001, China

  • 3.

    Department of Gastroenterology, Yangzhou First People’s Hospital, Yangzhou, Jiangsu 225009, China

  • 4.

    Section of Clinical Epidemiology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, Jiangsu 210029, China

Funds: 

National Natural Science Foundation of China (No. 81001276 and No. 81072380) and a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions

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    Graphical Abstract
    • Abstract
  • MET tyrosine kinase and its ligand, hepatocyte growth factor (HGF), play a pivotal role in the activties of tumor cells. A germline missense variant in exon 2 of the MET gene, N375S (rs33917957 A>G), may alter the binding affinity of MET for HGF and thus modify the risk of tumorigenesis. In this study, we performed a case-control study to assess the association between N375S and gastric cancer risk in 1,681 gastric cancer cases and 1,858 cancer-free controls. Logistic regression analysis was applied to estimate crude and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the associations between genotypes and gastric cancer risk. We found that MET N375S variant genotypes (NS/SS) were associated with a significantly decreased risk of gastric cancer (OR = 0.78, 95% CI = 0.63-0.96, P = 0.021) compared with the wildtype homozygote (NN). The finding indicates that this germline variant in MET may decrease gastric cancer susceptibility in Han Chinese.
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