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  • CN 32-1810/R
Volume 36 Issue 1
Jan.  2022
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Trupti N. Patel, Pavan Kumar Dhanyamraju. Role of aberrant Sonic hedgehog signaling pathway in cancers and developmental anomalies[J]. The Journal of Biomedical Research, 2022, 36(1): 1-9. DOI: 10.7555/JBR.35.20210139
Citation: Trupti N. Patel, Pavan Kumar Dhanyamraju. Role of aberrant Sonic hedgehog signaling pathway in cancers and developmental anomalies[J]. The Journal of Biomedical Research, 2022, 36(1): 1-9. DOI: 10.7555/JBR.35.20210139
shu

Role of aberrant Sonic hedgehog signaling pathway in cancers and developmental anomalies

  • 1.

    School of Biosciences and Technology, Vellore Institute of Technology, Vellore Campus, Vellore, Tamil Nadu 632014, India

  • 2.

    Department of Pharmacology, Penn State University College of Medicine, Hershey, PA 17033, USA

  • 3.

    Penn State Cancer Institute, Hershey, PA 17033, USA

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  • Corresponding author:

    Pavan Kumar Dhanyamraju, Department of Pharmacology, Penn State University College of Medicine and Penn State Cancer Institute, Hershey, PA 17033, USA. Tel: +1-6096474712, E-mail: biopan@gmail.com

  • Received Date: August 22, 2021
  • Revised Date: September 08, 2021
  • Accepted Date: September 12, 2021
  • Available Online: December 14, 2021
    Abstract
  • Development is a sophisticated process maintained by various signal transduction pathways, including the Hedgehog (Hh) pathway. Several important functions are executed by the Hh signaling cascade such as organogenesis, tissue regeneration, and tissue homeostasis, among various others. Considering the multiple functions carried out by this pathway, any mutation causing aberrant Hh signaling may lead to myriad developmental abnormalities besides cancers. In the present review article, we explored a wide range of diseases caused by aberrant Hh signaling, including developmental defects and cancers. Finally, we concluded this mini-review with various treatment strategies for Hh-induced diseases.
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    • References (85)
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    Corresponding author: Pavan Kumar Dhanyamraju, biopan@gmail.com
    • 2.

      Department of Pharmacology, Penn State University College of Medicine, Hershey, PA 17033, USA

    • 3.

      Penn State Cancer Institute, Hershey, PA 17033, USA

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