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  • ISSN 1674-8301
  • CN 32-1810/R
Hilla Knobler, Ari Elson. Metabolic regulation by protein tyrosine phosphatases[J]. The Journal of Biomedical Research, 2014, 28(3): 157-168. DOI: 10.7555/JBR.28.20140012
Citation: Hilla Knobler, Ari Elson. Metabolic regulation by protein tyrosine phosphatases[J]. The Journal of Biomedical Research, 2014, 28(3): 157-168. DOI: 10.7555/JBR.28.20140012

Metabolic regulation by protein tyrosine phosphatases

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This work was supported by the Israel Science Foundation (#786/13), the Fritz Thyssen Stiftung (Germany), and by the Kekst Family Institute for Medical Genetics and the David and Fela Shapell Family Center for Genetic Disorders Research at the Weizmann Institute.

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  • Received Date: January 01, 2014
  • Obesity and the metabolic syndrome and their associated morbidities are major public health issues, whose prevalence will continue to increase in the foreseeable future. Aberrant signaling by the receptors for leptin and insulin plays a pivotal role in development of the metabolic syndrome. More complete molecular-level understanding of how both of these key signaling pathways are regulated is essential for full characterization of obesity, the metabolic syndrome, and type II diabetes, and for developing novel treatments for these diseases. Phosphorylation of proteins on tyrosine residues plays a key role in mediating the effects of leptin and insulin on their target cells. Here, we discuss the molecular methods by which protein tyrosine phosphatases, which are key physiological regulators of protein phosphorylation in vivo, affect signaling by the leptin and insulin receptors in their major target tissues.
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