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  • ISSN 1674-8301
  • CN 32-1810/R
Volume 26 Issue 5
Aug.  2012
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Xiaodong Yang, Ping Huang, Feng Wang, Zekuan Xu, Xiaonin Wang. Growth hormone receptor expression in human primary gastric adenocarcinoma[J]. The Journal of Biomedical Research, 2012, 26(5): 307-314. DOI: 10.7555/JBR.26.20110133
Citation: Xiaodong Yang, Ping Huang, Feng Wang, Zekuan Xu, Xiaonin Wang. Growth hormone receptor expression in human primary gastric adenocarcinoma[J]. The Journal of Biomedical Research, 2012, 26(5): 307-314. DOI: 10.7555/JBR.26.20110133
shu

Growth hormone receptor expression in human primary gastric adenocarcinoma

  • 1.

    Department of General Surgery, the First Affiliated Hospital, the Nanjing Medical University, Nanjing, Jiangsu 210029, China

  • 2.

    Department of General Surgery, Jiangsu Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing, Jiangsu 210028, China

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  • Received Date: November 10, 2011
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    • Abstract
  • The aim of this study was to determine the expression of growth hormone receptor (GHR) in patients with primary gastric adenocarcinoma. We investigated 48 specimens of primary gastric adenocarcinoma and their corresponding normal gastric mucosa. Immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR) were used to detect the expression of GHR. Immunohistochemical analyses revealed that GHR was expressed in human primary gastric adenocarcinoma (36/48, 75.0%) and appeared to be upregulated, compared to the normal mucosa (28/48, 58.3%, P < 0.001). A significant correlation was found between GHR expression and tumor stage (P < 0.001) and tumor differentiation (P < 0.001). The average positive rate of ki-67 in GHR-positive tumors was 16.06%, while the positive rate in GHR-negative tumors was 6.17% (P < 0.01). The average apoptosis index (AI) of GHR-positive tumors was 3.36%, which was significantly lower than that (7.33%) of GHR-negative tumors. In addition, 27 of 48 cases of tumors had GHR mRNA expression, while only 17 of all 48 cases of normal mucosa did so. Our results indicate that the frequency of GHR was significantly higher in primary gastric adenocarcinoma than that in normal gastric mucosa. GHR expression was significantly correlated with tumor differentiation and tumor grade. This finding supported a possible role of growth hormone in primary gastric adenocarcinoma pathophysiology.
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