Figures of the Article

• OX2R agonist OB-Ala reduced energy expenditure and food intake.
• OB-Ala inhibited thermogenesis of brown adipose tissue.
• OX2R is selectively expressed in brown adipose tissue and does not affect white adipose tissue.
• OB-Ala reduced sympathetic innervation of iBAT and POMC expression in the hypothalamus.
• OB-Ala had no effect on thermogenic genes in primary brown adipocytes.
• OX2R is located at afferent nerve endings innervating brown adipose tissue.
• Intra-BAT infusion of OB-Ala inhibited iBAT thermogenesis during cold exposure.