4.6

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2.2

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  • ISSN 1674-8301
  • CN 32-1810/R
Liu Shuying, Lu Shan. Antibody responses in COVID-19 patients[J]. The Journal of Biomedical Research, 2020, 34(6): 410-415. DOI: 10.7555/JBR.34.20200134
Citation: Liu Shuying, Lu Shan. Antibody responses in COVID-19 patients[J]. The Journal of Biomedical Research, 2020, 34(6): 410-415. DOI: 10.7555/JBR.34.20200134

Antibody responses in COVID-19 patients

More Information
  • Corresponding author:

    Shan Lu, Department of Medicine, University of Massachusetts Medical School, 364 Plantation St. Worcester, MA 01605, USA. Tel/Fax: +1-508-856-6791/+1-508-856-6751, E-mail: shan.lu@umassmed.edu

  • Received Date: August 03, 2020
  • Available Online: September 10, 2020
  • Measuring virus-specific antibody responses to emerging pathogens is a well-established and highly useful tool to diagnose such infections, understand interactions between the immune system and pathogens, and provide potential clues for the development of vaccines or therapeutic agents against such pathogens. Since the beginning of 2020, the discovery of SARS-CoV-2 as the emerging virus responsible for the COVID-19 pandemic has provided new insight into the complexity of antibody responses to this dangerous virus. The current review aims to sort out diverse and sometimes seemingly confusing findings to put together a cohesive understanding on the profile of antibody responses elicited in COVID-19 patients.
  • [1]
    Li TS, Lu HZ, Zhang WH. Clinical observation and management of COVID-19 patients[J]. Emerg Microbes Infect, 2020, 9(1): 687–690. doi: 10.1080/22221751.2020.1741327
    [2]
    Zhang W, Du RH, Li B, et al. Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes[J]. Emerg Microbes Infect, 2020, 9(1): 386–389. doi: 10.1080/22221751.2020.1729071
    [3]
    Sun BQ, Feng Y, Mo XN, et al. Kinetics of SARS-CoV-2 specific IgM and IgG responses in COVID-19 patients[J]. Emerg Microbes Infect, 2020, 9(1): 940–948. doi: 10.1080/22221751.2020.1762515
    [4]
    Orth-Höller D, Eigentler A, Weseslindtner L, et al. Antibody kinetics in primary- and secondary-care physicians with mild to moderate SARS-CoV-2 infection[J]. Emerg Microbes Infect, 2020, 9(1): 1692–1694. doi: 10.1080/22221751.2020.1793690
    [5]
    Shen L, Wang CH, Zhao JZ, et al. Delayed specific IgM antibody responses observed among COVID-19 patients with severe progression[J]. Emerg Microbes Infect, 2020, 9(1): 1096–1101. doi: 10.1080/22221751.2020.1766382
    [6]
    Xu Y, Xiao M, Liu XC, et al. Significance of serology testing to assist timely diagnosis of SARS-CoV-2 infections: implication from a family cluster[J]. Emerg Microbes Infect, 2020, 9(1): 924–927. doi: 10.1080/22221751.2020.1752610
    [7]
    Chia WN, Tan CW, Foo R, et al. Serological differentiation between COVID-19 and SARS infections[J]. Emerg Microbes Infect, 2020, 9(1): 1497–1505. doi: 10.1080/22221751.2020.1780951
    [8]
    Wu F, Liu M, Wang AJ, et al. Evaluating the association of clinical characteristics with neutralizing antibody levels in patients who have recovered from mild COVID-19 in Shanghai, China[J]. JAMA Intern Med, 2020. doi: 10.1001/jamainternmed.2020.4616. [Epub ahead of print
    [9]
    Anderson DE, Tan CW, Chia WN, et al. Lack of cross-neutralization by SARS patient sera towards SARS-CoV-2[J]. Emerg Microbes Infect, 2020, 9(1): 900–902. doi: 10.1080/22221751.2020.1761267
    [10]
    Liu XM, Wang J, Xu XL, et al. Patterns of IgG and IgM antibody response in COVID-19 patients[J]. Emerg Microbes Infect, 2020, 9(1): 1269–1274. doi: 10.1080/22221751.2020.1773324
    [11]
    To KKW, Tsang OTY, Leung WS, et al. Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study[J]. Lancet Infect Dis, 2020, 20(5): 565–574. doi: 10.1016/S1473-3099(20)30196-1
    [12]
    Long QX, Liu BZ, Deng HJ, et al. Antibody responses to SARS-CoV-2 in patients with COVID-19[J]. Nat Med, 2020, 26(6): 845–848. doi: 10.1038/s41591-020-0897-1
    [13]
    Zhang YC, Shen H, Wang XN, et al. Different longitudinal patterns of nucleic acid and serology testing results based on disease severity of COVID-19 patients[J]. Emerg Microbes Infect, 2020, 9(1): 833–836. doi: 10.1080/22221751.2020.1756699
    [14]
    Wang SX, Chou THW, Sakhatskyy PV, et al. Identification of two neutralizing regions on the severe acute respiratory syndrome coronavirus spike glycoprotein produced from the mammalian expression system[J]. J Virol, 2005, 79(3): 1906–1910. doi: 10.1128/JVI.79.3.1906-1910.2005
    [15]
    Liu L, To KKW, Chan KH, et al. High neutralizing antibody titer in intensive care unit patients with COVID-19[J]. Emerg Microbes Infect, 2020, 9(1): 1664–1670. doi: 10.1080/22221751.2020.1791738
    [16]
    Liu L, Wei Q, Lin QQ, et al. Anti-spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection[J]. JCI Insight, 2019, 4(4): e123158. doi: 10.1172/jci.insight.123158
    [17]
    Wang PF, Liu LH, Nair MS, et al. SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease[J]. Emerg Microbes Infect, 2020, 9(1): 2091–2093. doi: 10.1080/22221751.2020.1823890
    [18]
    Liu PC, Cai JH, Jia R, et al. Dynamic surveillance of SARS-CoV-2 shedding and neutralizing antibody in children with COVID-19[J]. Emerg Microbes Infect, 2020, 9(1): 1254–1258. doi: 10.1080/22221751.2020.1772677
    [19]
    Chen HJ, Guo JJ, Wang C, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records[J]. Lancet, 2020, 395(10226): 809–815. doi: 10.1016/S0140-6736(20)30360-3
    [20]
    Dong YZ, Chi XY, Hai H, et al. Antibodies in the breast milk of a maternal woman with COVID-19[J]. Emerg Microbes Infect, 2020, 9(1): 1467–1469. doi: 10.1080/22221751.2020.1780952
    [21]
    GeurtsvanKessel CH, Okba NMA, Igloi Z, et al. An evaluation of COVID-19 serological assays informs future diagnostics and exposure assessment[J]. Nat Commun, 2020, 11(1): 3436. doi: 10.1038/s41467-020-17317-y
    [22]
    Bastos ML, Tavaziva G, Abidi SK, et al. Diagnostic accuracy of serological tests for covid-19: systematic review and meta-analysis[J]. BMJ, 2020, 370: m2516. doi: 10.1136/bmj.m2516
    [23]
    Wang H, Ai J, Loeffelholz M, et al. Meta-analysis of diagnostic performance of serology tests for COVID-19: Impact of assay design and post-symptom-onset intervals[J]. Emerg Microbes Infect, 2020. doi: 10.1080/22221751.2020.1826362. [Epub ahead of print
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