4.6

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  • ISSN 1674-8301
  • CN 32-1810/R
Volume 31 Issue 3
Apr.  2017
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Yueying Li, Jun Liu, Xiaoming Yang, Yan Dong, Yali Liu, Min Chen. Ginkgol C17:1 inhibits tumor growth by blunting the EGF-PI3K/Akt signaling pathway[J]. The Journal of Biomedical Research, 2017, 31(3): 232-239. DOI: 10.7555/JBR.31.20160039
Citation: Yueying Li, Jun Liu, Xiaoming Yang, Yan Dong, Yali Liu, Min Chen. Ginkgol C17:1 inhibits tumor growth by blunting the EGF-PI3K/Akt signaling pathway[J]. The Journal of Biomedical Research, 2017, 31(3): 232-239. DOI: 10.7555/JBR.31.20160039
shu

Ginkgol C17:1 inhibits tumor growth by blunting the EGF-PI3K/Akt signaling pathway

  • 1.

    School of Medicine, Institute of Life Sciences

  • 2.

    Institute of Life Sciences

  • 3.

    School of Food and Biological Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, China

  • 4.

    School of Medicine

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  • Received Date: March 20, 2016
  • Revised Date: April 27, 2016
    Graphical Abstract
    • Abstract
  • Ginkgol C17:1 has been shown to inhibit apoptosis and migration of cancer cells, but the underlying mechanisms are not fully elucidated. In this study, we explored whether the inhibitory effects of Ginkgol C17:1 were associated with epidermal growth factor receptor (EGFR) and PI3K/Akt signaling. The results showed that EGF treatment increased the phosphorylation of EGFR, PI3K, Akt, mTOR and NF-kB, and also enhanced the proliferation, migration and invasion of HepG2 cells. Ginkgol C17:1 dose-dependently inhibited EGF-induced phosphorylation/activation of all the key components including EGFR, PI3K, Akt, mTOR and NF-kB, leading to a significant reduction either of proliferation or migration and invasion of HepG2 cells. Notably, treatment with Ginkgol C17:1 in mice suppressed the growth of tumor mass in vivo, and expression of EGFR in the tumor tissue. The results suggest that Ginkgol C17:1 is a potent tumor inhibiting compound that acts on EGF-induced signal transduction of the PI3K/vjjhhAkt signaling pathways, and may represent a clinically interesting candidate for cancer therapy.
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