• ISSN 1674-8301
  • CN 32-1810/R
Volume 29 Issue 3
May  2015
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Article Contents
Cheng Tang, Feng Wang, Yanjie Hou, Shanshan Lu, Wei Tian, Yan Xu, Chengzhe Jin, Liming Wang. Technetium-99m-labeled annexin V imaging for detecting prosthetic joint infection in a rabbit model[J]. The Journal of Biomedical Research, 2015, 29(3): 224-231. doi: 10.7555/JBR.29.20130113
Citation: Cheng Tang, Feng Wang, Yanjie Hou, Shanshan Lu, Wei Tian, Yan Xu, Chengzhe Jin, Liming Wang. Technetium-99m-labeled annexin V imaging for detecting prosthetic joint infection in a rabbit model[J]. The Journal of Biomedical Research, 2015, 29(3): 224-231. doi: 10.7555/JBR.29.20130113

Technetium-99m-labeled annexin V imaging for detecting prosthetic joint infection in a rabbit model

doi: 10.7555/JBR.29.20130113
  • Received: 2013-07-24
  • Revised: 2013-09-03
  • Issue Date: 2015-05-29
  • Accurate and timely diagnosis of prosthetic joint infection is essential to initiate early treatment and achieve a favorable outcome. In this study, we used a rabbit model to assess the feasibility of technetium-99m-labeled annexin V for detecting prosthetic joint infection. Right knee arthroplasty was performed on 24 New Zealand rabbits. After surgery, methicillin-susceptible Staphylococcus aureus was intra-articularly injected to create a model of prosthetic joint infection (the infected group, n512). Rabbits in the control group were injected with sterile saline (n512). Seven and 21 days after surgery, technetium-99m-labeled annexin V imaging was performed in 6 rabbits of each group. Images were acquired 1 and 4 hours after injection of technetium-99mlabeled annexin V (150 MBq). The operated-to-normal-knee activity ratios were calculated for quantitative analysis. Seven days after surgery, increased technetium-99m-labeled annexin V uptake was observed in all cases. However, at 21 days a notable decrease was found in the control group, but not in the infected group. The operated-to-normal-knee activity ratios of the infected group were 1.84 ? 0.29 in the early phase and 2.19 ? 0.34 in the delay phase, both of which were significantly higher than those of the control group (P50.03 and P50.02). The receiver operator characteristic curve analysis showed that the operated-to-normal-knee activity ratios of the delay phase at 21 days was the best indicator, with an accuracy of 80%. In conclusion, technetium-99m-labeled annexin V imaging could effectively distinguish an infected prosthetic joint from an uninfected prosthetic joint in a rabbit model.

     

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