Clopidogrel improves aspirin response after off-pump coronary artery bypass surgery
This work was supported by a grant from the National Natural Science Foundation of China (81170181), and a Program for Development of Innovative Research Team in the First Affiliated Hospital of Nanjing Medical University, and a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutes (PAPD).
- Received Date: 2012-12-14
- Publish Date: 2014-03-28
Abstract: We sought to assess the incidence of aspirin resistance after off-pump coronary artery bypass (OPCAB) surgery, and investigate whether clopidogrel can improve aspirin response and be safely applied early after OPCAB surgery. Sixty patients who underwent standard OPCAB surgery were randomized into two groups. One group (30 patients) received mono-antiplatelet treatment (MAPT) with aspirin 100 mg daily and the other group received dual antiplatelet treatment (DAPT) with aspirin 100 mg daily plus clopidogrel 75 mg daily. Platelet aggregations in response to arachidonic acid (PLAA) and adenosine diphosphate (ADP) (PLADP) were measured preoperatively and on days 1 to 6, 8 and 10 after the antiplatelet agents were administered. A PLAA level above 20% was defined as aspirin resistance. Postoperative bleeding and other perioperative variables were also recorded. There were no significant differences between the two groups in baseline characteristics, average number of distal anastomosis, operation time, postoperative bleeding, ventilation time and postoperative hospital stay. However, the incidence of aspirin resistance was significantly lower in the DAPT group than that in the MAPT group on the first and second day after antiplatelet agents were given (62.1% vs. 32.1%, 34.5% vs. 10.7%, respectively, both P , 0.05). There was no significant difference in postoperative complication between the two groups. DAPT with aspirin and clopidogrel can be safely applied to OPCAB patients early after the procedure. Moreover, clopidogrel reduces the incidence of OPCAB-related aspirin resistance.
|Citation:||Xuezhong Wang, Xiaoxuan Gong, Tiantian Zhu, Qiu Zhang, Yangyang Zhang, Xiaowei Wang, Zhijian Yang, Chunjian Li. Clopidogrel improves aspirin response after off-pump coronary artery bypass surgery[J]. The Journal of Biomedical Research, 2014, 28(2): 108-113. doi: 10.7555/JBR.28.20120139|