Acquired immunity and Alzheimer's disease

Weixi Feng; Yanli Zhang; Peng Sun; Ming Xiao

doi:10.7555/JBR.36.20220083

Volume 37 Issue 1

Jan. 2023

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Article Navigation > The Journal of Biomedical Research > 2023 > 37(1): 15-29

Weixi Feng, Yanli Zhang, Peng Sun, Ming Xiao. Acquired immunity and Alzheimer's disease[J]. The Journal of Biomedical Research, 2023, 37(1): 15-29. doi: 10.7555/JBR.36.20220083

Citation:

Weixi Feng, Yanli Zhang, Peng Sun, Ming Xiao. Acquired immunity and Alzheimer's disease[J]. The Journal of Biomedical Research, 2023, 37(1): 15-29. doi: 10.7555/JBR.36.20220083

Weixi Feng, Yanli Zhang, Peng Sun, Ming Xiao. Acquired immunity and Alzheimer's disease[J]. The Journal of Biomedical Research, 2023, 37(1): 15-29. doi: 10.7555/JBR.36.20220083

Citation:

Weixi Feng, Yanli Zhang, Peng Sun, Ming Xiao. Acquired immunity and Alzheimer's disease[J]. The Journal of Biomedical Research, 2023, 37(1): 15-29. doi: 10.7555/JBR.36.20220083

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Acquired immunity and Alzheimer's disease

doi: 10.7555/JBR.36.20220083

Weixi Feng^{1, 2
,
,},
Yanli Zhang^{1, 3},
Peng Sun^{1, 3},
Ming Xiao^{1, 2, 3}

1.
Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing, Jiangsu 211166, China
2.
Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, Chinese Academy of Sciences, Shanghai 200031, China
3.
Brain Institute, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China

More Information

Corresponding author: Weixi Feng, Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, Jiangsu 211166, China. Tel: +86-25-86869338; E-mail: weixif@njmu.edu.cn
Received: 2022-04-13
Revised: 2022-06-18
Accepted: 2022-06-27

Published: 2022-07-28

Issue Date: 2023-01-28

Abstract

Abstract

Alzheimer's disease (AD) is an age-related neurodegenerative disease characterized by progressive cognitive defects. The role of the central immune system dominated by microglia in the progression of AD has been extensively investigated. However, little is known about the peripheral immune system in AD pathogenesis. Recently, with the discovery of the meningeal lymphatic vessels and glymphatic system, the roles of the acquired immunity in the maintenance of central homeostasis and neurodegenerative diseases have attracted an increasing attention. The T cells not only regulate the function of neurons, astrocytes, microglia, oligodendrocytes and brain microvascular endothelial cells, but also participate in the clearance of β-amyloid (Aβ) plaques. Apart from producing antibodies to bind Aβ peptides, the B cells affect Aβ-related cascades via a variety of antibody-independent mechanisms. This review systemically summarizes the recent progress in understanding pathophysiological roles of the T cells and B cells in AD.
- Alzheimer's disease,
- acquired immunity,
- lymphocytes,
- brain lymphatic system,
- immune cell therapy

CLC number: R749.16, Document code: A
The authors reported no conflict of interests.

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References(150)

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