4.6

CiteScore

2.2

Impact Factor
  • ISSN 1674-8301
  • CN 32-1810/R
Volume 34 Issue 2
Mar.  2020
Turn off MathJax
Article Contents
Abstract
References
Related Articles
Tiwari-Heckler Shilpa, Jiang Z. Gordon, Popov Yury, J. Mukamal Kenneth. Daily high-dose aspirin does not lower APRI in the Aspirin-Myocardial Infarction Study[J]. The Journal of Biomedical Research, 2020, 34(2): 139-142. DOI: 10.7555/JBR.33.20190041
Citation: Tiwari-Heckler Shilpa, Jiang Z. Gordon, Popov Yury, J. Mukamal Kenneth. Daily high-dose aspirin does not lower APRI in the Aspirin-Myocardial Infarction Study[J]. The Journal of Biomedical Research, 2020, 34(2): 139-142. DOI: 10.7555/JBR.33.20190041
shu

Daily high-dose aspirin does not lower APRI in the Aspirin-Myocardial Infarction Study

  • 1.

    Division of Gastroenterology and Hepatology, Department of Medicine

  • 2.

    Division of General Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA

Funds: This is an open access article under the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited
More Information
  • Corresponding author:

    Z. Gordon Jiang, Division of Gastroenterology and Hepatology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA. Tel/Fax: +1-617-667-2136/+1-617-667-2767, Email: zgjiang@bidmc.harvard.edu

  • Received Date: March 17, 2019
  • Revised Date: June 29, 2019
  • Accepted Date: August 19, 2019
  • Available Online: October 23, 2019
    Graphical Abstract
    • Abstract
  • Antiplatelet agents reduce liver fibrosis by inhibiting platelet activation and platelet-derived growth factor production. Previous cross-sectional epidemiological studies suggest that the use of aspirin is related to reduced liver fibrosis. The Aspirin-Myocardial Infarction Study (AMIS) aims to examine this relationship in a multicenter, randomized, double-blind and placebo-controlled trial. The existing clinical trial of aspirin was conducted to study the benefit of one gram aspirin daily among 4 524 individuals who had experienced at least one documented myocardial infarction. The aspartate aminotransferase (AST)-to-Platelet Ratio Index (APRI) was calculated at baseline and annually from the platelet count and AST levels. Participants in the AMIS trial had a mean baseline APRI of 0.34±0.36, and only 1% individuals had APRI scores higher than 1.0, a common cutoff for cirrhosis. The daily use of aspirin was associated with an increase, rather than a reduction of APRI, by 0.007 per year (95% CI 0.002−0.015, P=0.12). The use of aspirin did not significantly affect platelet counts. In a sensitivity analysis of individuals with probable significant fibrosis at baseline (APRI≥0.7), the aspirin group had a sustained reduction in APRI over time, although this change was not significant compared to that in the placebo group. In the AMIS trial, the daily use of high-dose aspirin did not significantly affect APRI, a surrogate index of liver fibrosis. This study highlights the need for de novo clinical trials to investigate the potential benefit of antiplatelet agents on liver fibrosis.
    • FullText(HTML)
    • References (13)
  • [1]
    Gawaz M, Vogel S. Platelets in tissue repair: control of apoptosis and interactions with regenerative cells[J]. Blood, 2013, 122(15): 2550–2554. doi: 10.1182/blood-2013-05-468694
    [2]
    Bataller R, Brenner DA. Liver fibrosis[J]. J Clin Invest, 2005, 115(2): 209–218. doi: 10.1172/JCI24282
    [3]
    Pellicoro A, Ramachandran P, Iredale JP, et al. Liver fibrosis and repair: immune regulation of wound healing in a solid organ[J]. Nat Rev Immunol, 2014, 14(3): 181–194. doi: 10.1038/nri3623
    [4]
    Yoshida S, Ikenaga N, Liu SB, et al. Extra-hepatic PDGFB, delivered by platelets, promotes activation of hepatic stellate cells and biliary fibrosis in mice[J]. Gastroenterology, 2014, 147(6): 1378–1392. doi: 10.1053/j.gastro.2014.08.038
    [5]
    Chauhan A, Adams DH, Watson SP, at al. Platelets: no longer bystanders in liver disease[J]. Hepatology, 2016, 64(5): 1774–1784. doi: 10.1002/hep.28526
    [6]
    Fujita K, Nozaki Y, Wada K, et al. Effectiveness of antiplatelet drugs against experimental non-alcoholic fatty liver disease[J]. Gut, 2008, 57(11): 1583–1591. doi: 10.1136/gut.2007.144550
    [7]
    Jiang ZG, Feldbrügge L, Tapper EB, et al. Aspirin use is associated with lower indices of liver fibrosis among adults in the United States[J]. Aliment Pharmacol Ther, 2016, 43(6): 734–743. doi: 10.1111/apt.13515
    [8]
    Schwarzkopf K, Bojunga J, Rüschenbaum S, et al. Use of antiplatelet agents is inversely associated with liver fibrosis in patients with cardiovascular disease[J]. Hepatol Commun, 2018, 2(12): 1601–1609. doi: 10.1002/hep4.1254
    [9]
    From the Aspirin Myocardial Infarction Study Research Group. A randomized, controlled trial of aspirin in persons recovered from myocardial infarction[J]. JAMA, 1980, 243(7): 661–669. doi: 10.1001/jama.1980.03300330019023
    [10]
    Wai CT, Greenson JK, Fontana RJ, et al. A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C[J]. Hepatology, 2003, 38(2): 518–526. doi: 10.1053/jhep.2003.50346
    [11]
    Poujol-Robert A, Boelle PY, Conti F, et al. Aspirin may reduce liver fibrosis progression: Evidence from a multicenter retrospective study of recurrent hepatitis C after liver transplantation[J]. Clin Res Hepatol Gastroenterol, 2014, 38(5): 570–576. doi: 10.1016/j.clinre.2014.07.004
    [12]
    Sitia G, Aiolfi R, Di Lucia P, et al. Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B[J]. Proc Natl Acad Sci USA, 2012, 109(32): E2165–E2172. doi: 10.1073/pnas.1209182109
    [13]
    Simon TG, Ma YN, Ludvigsson JF, et al. Association between aspirin use and risk of hepatocellular carcinoma[J]. JAMA Oncol, 2018, 4(12): 1683–1690. doi: 10.1001/jamaoncol.2018.4154
    • Related Articles

  • Related Articles

    [1]Chen Li, Kerui Wang, Xingfeng Mao, Xiuxiu Liu, Yingmei Lu. Upregulated inwardly rectifying K+ current-mediated hypoactivity of parvalbumin interneuron underlies autism-like deficits in Bod1-deficient mice[J]. The Journal of Biomedical Research. DOI: 10.7555/JBR.38.20240394
    [2]Leonid N. Maslov, Natalia V. Naryzhnaya, Maria Sirotina, Alexandr V. Mukhomedzyanov, Boris K. Kurbatov, Alla A. Boshchenko, Huijie Ma, Yi Zhang, Feng Fu, Jianming Pei, Viacheslav N. Azev, Vladimir A. Pereverzev. Do reactive oxygen species damage or protect the heart in ischemia and reperfusion? Analysis on experimental and clinical data[J]. The Journal of Biomedical Research, 2023, 37(4): 255-267. DOI: 10.7555/JBR.36.20220261
    [3]Tiwari-Heckler Shilpa, Jiang Z. Gordon, Popov Yury, J. Mukamal Kenneth. Daily high-dose aspirin does not lower APRI in the Aspirin-Myocardial Infarction Study[J]. The Journal of Biomedical Research, 2020, 34(2): 139-142. DOI: 10.7555/JBR.33.20190041
    [4]Tao Chun'ai, Gan Yongxin, Su Weidong, Li Zhutian, Tang Xiaolan. Effectiveness of hospital disinfection and experience learnt from 11 years of surveillance[J]. The Journal of Biomedical Research, 2019, 33(6): 408-413. DOI: 10.7555/JBR.33.20180118
    [5]Huan Liu, Shijiang Zhang, Yongfeng Shao, Xiaohu Lu, Weidong Gu, Buqing Ni, Qun Gu, Junjie Du. Biomechanical characterization of a novel ring connector for sutureless aortic anastomosis[J]. The Journal of Biomedical Research, 2018, 32(6): 454-460. DOI: 10.7555/JBR.31.20170011
    [6]Minbo Zang, Qiao Zhou, Yunfei Zhu, Mingxi Liu, Zuomin Zhou. Effects of chemotherapeutic agent bendamustine for nonhodgkin lymphoma on spermatogenesis in mice[J]. The Journal of Biomedical Research, 2018, 32(6): 442-453. DOI: 10.7555/JBR.31.20170023
    [7]Huanqiang Wang, Congying Yang, Siyuan Wang, Tian Wang, Jingling Han, Kai Wei, Fucun Liu, Jida Xu, Xianzhen Peng, Jianming Wang. Cell-free plasma hypermethylated CASZ1, CDH13 and ING2 are promising biomarkers of esophageal cancer[J]. The Journal of Biomedical Research, 2018, 32(6): 424-433. DOI: 10.7555/JBR.32.20170065
    [8]Fengzhen Wang, Mingwan Zhang, Dongsheng Zhang, Yuan Huang, Li Chen, Sunmin Jiang, Kun Shi, Rui Li. Preparation, optimization, and characterization of chitosancoated solid lipid nanoparticles for ocular drug delivery[J]. The Journal of Biomedical Research, 2018, 32(6): 411-423. DOI: 10.7555/JBR.32.20160170
    [9]Jiawei Liao, Wei Huang, George Liu. Animal models of coronary heart disease[J]. The Journal of Biomedical Research, 2017, 31(1): 3-10. DOI: 10.7555/JBR.30.20150051
    [10]Sundeep?S.?Tumber, Hong?Liu. Epidural abscess after multiple lumbar punctures for labour epidural catheter placement[J]. The Journal of Biomedical Research, 2010, 24(4): 332-335. DOI: 10.1016/S1674-8301(10)60046-2

Catalog

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (3248) PDF downloads (111) Cited by()
    Related

    ©2023 by the Editorial Department of the Journals of Nanjing Medical University. All rights reserved.   苏ICP备05071376号-5

    Supported by: Beijing Renhe Information Technology Co., Ltd. E-mail: info@rhhz.net  Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return