Alexander E. Berezin, Alexander A. Kremzer, Tatayna A. Samura. Circulating thrombospondin-2 in patients with moderate-to-severe chronic heart failure due to coronary artery disease[J]. The Journal of Biomedical Research, 2016, 30(1): 32-39. DOI: 10.7555/JBR.30.20140025
Citation:
Alexander E. Berezin, Alexander A. Kremzer, Tatayna A. Samura. Circulating thrombospondin-2 in patients with moderate-to-severe chronic heart failure due to coronary artery disease[J]. The Journal of Biomedical Research, 2016, 30(1): 32-39. DOI: 10.7555/JBR.30.20140025
Alexander E. Berezin, Alexander A. Kremzer, Tatayna A. Samura. Circulating thrombospondin-2 in patients with moderate-to-severe chronic heart failure due to coronary artery disease[J]. The Journal of Biomedical Research, 2016, 30(1): 32-39. DOI: 10.7555/JBR.30.20140025
Citation:
Alexander E. Berezin, Alexander A. Kremzer, Tatayna A. Samura. Circulating thrombospondin-2 in patients with moderate-to-severe chronic heart failure due to coronary artery disease[J]. The Journal of Biomedical Research, 2016, 30(1): 32-39. DOI: 10.7555/JBR.30.20140025
Chronic heart failure (CHF) remains a leading cause of morbidity and mortality. In the current study, we aimed to evaluate the predictive value of circulating thrombospondin-2 (TSP-2) for cumulative survival in patients with ischemic CHF due to coronary artery disease (CAD). The results showed that during a median follow-up of 2.18 years, 21 participants died and 106 subjects were hospitalized repeatedly. The median circulating levels of TSP-2 in patients who survived and those who died were 0.63 ng/mL (95%CI50.55-0.64 ng/mL) and 1.03 ng/mL (95% CI50.97-1.07 ng/mL) (P,0.001). Circulating TSP-2 independently predicted all-cause mortality (OR51.27; 95%CI51.08-1.59; P50.002), CHF-related death (OR51.16; 95%CI51.02-1.50; P,0.001), and also CHF-related rehospitalization (OR51.12; 95%CI51.07-1.25; P,0.001). In conclusion, among CAD patients with symptomatic CHF, increased circulating TSP-2 is correlated with increased 3-year CHF-related death, all-cause mortality, and risk for recurrent hospitalization.
Atabati H, Raoofi A, Amini A, et al. Evaluating HER2 Gene Amplification Using Chromogenic In Situ Hybridization (CISH) Method In Comparison To Immunohistochemistry Method in Breast Carcinoma. Open Access Maced J Med Sci, 2018, 6(11): 1977-1981.
DOI:10.3889/oamjms.2018.455