4.6

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2.2

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  • ISSN 1674-8301
  • CN 32-1810/R
Volume 26 Issue 3
Apr.  2012
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Abstract
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Jing Cai, Yanhui Sheng, Shijiang Zhang, Wei Sun, Rong Yang, Liping Miao, Xiangqing Kong. Preliminary feasibility and hemodynamic performance of a newly-developed self-expanding bioprosthesis and 16-F delivery system in transcatheter aortic valve implantation in sheep[J]. The Journal of Biomedical Research, 2012, 26(3): 211-218. DOI: 10.7555/JBR.26.20120011
Citation: Jing Cai, Yanhui Sheng, Shijiang Zhang, Wei Sun, Rong Yang, Liping Miao, Xiangqing Kong. Preliminary feasibility and hemodynamic performance of a newly-developed self-expanding bioprosthesis and 16-F delivery system in transcatheter aortic valve implantation in sheep[J]. The Journal of Biomedical Research, 2012, 26(3): 211-218. DOI: 10.7555/JBR.26.20120011
shu

Preliminary feasibility and hemodynamic performance of a newly-developed self-expanding bioprosthesis and 16-F delivery system in transcatheter aortic valve implantation in sheep

  • 1.

    Department of Cardiology,the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China.

  • 2.

    Department of Cardiac Surgery, the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China.

Funds: 

National High-Tech R&D Program of China ("863" Program, No. 2007AA02Z444).

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  • Received Date: February 07, 2012
    Graphical Abstract
    • Abstract
  • We sought to evaluate the feasibility and hemodynamic performance of a new self-expanding bioprosthesis and 16-F delivery system in sheep. A 23-mm new self-expanding aortic bioprosthesis was implanted in sheep (n = 10) with a 16-F catheter via the right common carotid artery. Each sheep underwent angiography and coronary angiography before intervention, immediately and 1 h after stent implantation. Electrocardiographic monitoring was carried out during and 2 h after the procedure. Transthoracic echocardiography was employed to detect hemodynamic performance before intervention, immediately and 1 and 2 h after stent implantation. All sheep were euthanized 2 h after successful implantation for macroscopic inspection. In all cases, the new self-expanding aortic bioprosthesis was successfully delivered to the aortic root and released with a 16-F catheter. Successful implantation was achieved in 8 of 10 sheep. Hemodynamic performance and device position of successful implantation were stable 2 h after device deployment. Atrioventricular block was not observed. We conclude that it is feasible to implant the new self-expanding aortic valve with a 16-F delivery system into sheep hearts via the retrograde route.
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