Yao Liu, Qin Zhang, Chuanli Ren, Yanbing Ding, Guangfu Jin, Zhibin Hu, Yaochu Xu, Hongbing Shen. A germline variant N375S in MET and gastric cancer susceptibility in a Chinese population[J]. The Journal of Biomedical Research, 2012, 26(5): 315-318. DOI: 10.7555/JBR.26.20110087
Citation:
Yao Liu, Qin Zhang, Chuanli Ren, Yanbing Ding, Guangfu Jin, Zhibin Hu, Yaochu Xu, Hongbing Shen. A germline variant N375S in MET and gastric cancer susceptibility in a Chinese population[J]. The Journal of Biomedical Research, 2012, 26(5): 315-318. DOI: 10.7555/JBR.26.20110087
Yao Liu, Qin Zhang, Chuanli Ren, Yanbing Ding, Guangfu Jin, Zhibin Hu, Yaochu Xu, Hongbing Shen. A germline variant N375S in MET and gastric cancer susceptibility in a Chinese population[J]. The Journal of Biomedical Research, 2012, 26(5): 315-318. DOI: 10.7555/JBR.26.20110087
Citation:
Yao Liu, Qin Zhang, Chuanli Ren, Yanbing Ding, Guangfu Jin, Zhibin Hu, Yaochu Xu, Hongbing Shen. A germline variant N375S in MET and gastric cancer susceptibility in a Chinese population[J]. The Journal of Biomedical Research, 2012, 26(5): 315-318. DOI: 10.7555/JBR.26.20110087
Department of Epidemiology and Biostatistics, MOE Key Laboratory of Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 210029, China
2.
Medical Laboratory, Northern Jiangsu People’s Hospital, Yangzhou, Jiangsu 225001, China
3.
Department of Gastroenterology, Yangzhou First People’s Hospital, Yangzhou, Jiangsu 225009, China
4.
Section of Clinical Epidemiology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, Jiangsu 210029, China
Funds:
National Natural Science Foundation of China (No. 81001276 and No. 81072380) and a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions
MET tyrosine kinase and its ligand, hepatocyte growth factor (HGF), play a pivotal role in the activties of tumor cells. A germline missense variant in exon 2 of the MET gene, N375S (rs33917957 A>G), may alter the binding affinity of MET for HGF and thus modify the risk of tumorigenesis. In this study, we performed a case-control study to assess the association between N375S and gastric cancer risk in 1,681 gastric cancer cases and 1,858 cancer-free controls. Logistic regression analysis was applied to estimate crude and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the associations between genotypes and gastric cancer risk. We found that MET N375S variant genotypes (NS/SS) were associated with a significantly decreased risk of gastric cancer (OR = 0.78, 95% CI = 0.63-0.96, P = 0.021) compared with the wildtype homozygote (NN). The finding indicates that this germline variant in MET may decrease gastric cancer susceptibility in Han Chinese.
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