4.6

CiteScore

2.2

Impact Factor
  • ISSN 1674-8301
  • CN 32-1810/R
Jianming Gao, Aizhen Yang, Min Chen, Ansheng Li, Xu Yao, Yumei Li, Shihai Xie, Xueyuan Yang, Liansheng Zhong, Zhiqiang Chen. mRNA profiles of cytokine receptors in unstimulated peripheral blood mononuclear cells from patients with chronic idiopathic urticaria[J]. The Journal of Biomedical Research, 2011, 25(2): 141-147. DOI: 10.1016/S1674-8301(11)60018-3
Citation: Jianming Gao, Aizhen Yang, Min Chen, Ansheng Li, Xu Yao, Yumei Li, Shihai Xie, Xueyuan Yang, Liansheng Zhong, Zhiqiang Chen. mRNA profiles of cytokine receptors in unstimulated peripheral blood mononuclear cells from patients with chronic idiopathic urticaria[J]. The Journal of Biomedical Research, 2011, 25(2): 141-147. DOI: 10.1016/S1674-8301(11)60018-3

mRNA profiles of cytokine receptors in unstimulated peripheral blood mononuclear cells from patients with chronic idiopathic urticaria

More Information
  • This present study was aimed to investigate the roles of the receptors of Th1/Th2 cytokines and chemokines in the pathogenesis of chronic idiopathic urticaria (CIU). Thirty patients with CIU, 30 patients with dermographism and 30 healthy controls were randomly enrolled. Reverse transcription-PCR (RT-PCR) was used to analyze the mRNA of cytokine receptors in peripheral blood mononuclear cells (PBMCs). The mRNA levels of tumor necro-sis factor receptor (TNFR), interferon-γ receptor (IFN-γR), and interleukin-10 receptor (IL-10R) were statistically increased in the CIU group (P < 0.05), while IL-2R, IL-4R, IL-6R, and IL-13R showed no significant differences between the CIU and other groups. The mRNA levels of CCR3 and CCR6 were statistically increased in the CIU group (P < 0.05). The toll-like receptor 2 (TLR2) mRNA level was significantly lower in the CIU group than the healthy control group (P < 0.05). These findings indicate that the regulation of mRNA of TNFR, IFN-γR, IL-10R, CCR3, CCR6 and TLR2 may be involved in the pathogenesis of CIU.
  • Related Articles

    [1]Gege Yuan, Jiachen Wang, Shuangshuang Qiu, Yunfei Zhu, Qing Cheng, Laihua Li, Jiahao Sha, Xiaoyu Yang, Yan Yuan. Title: Improving in vitro induction efficiency of human primordial germ cell-like cells using N2B27 or NAC-based medium[J]. The Journal of Biomedical Research. DOI: 10.7555/JBR.38.20240433
    [2]Motawi Tarek K, Ahmed Samia A, Hamed Manal A, El-Maraghy Shohda A, Aziz Wessam M. Melatonin and/or rowatinex attenuate streptozotocin-induced diabetic renal injury in rats[J]. The Journal of Biomedical Research, 2019, 33(2): 113-121. DOI: 10.7555/JBR.31.20160028
    [3]Hiyoshi Toru, Fujiwara Mutsunori, Yao Zemin. Postprandial hyperglycemia and postprandial hypertriglyceridemia in type 2 diabetes[J]. The Journal of Biomedical Research, 2019, 33(1): 1-16. DOI: 10.7555/JBR.31.20160164
    [4]Kaibo Lin, Shikun Zhang, Jieli Chen, Ding Yang, Mengyi Zhu, Eugene Yujun Xu. Generation and functional characterization of a conditional Pumilio2 null allele[J]. The Journal of Biomedical Research, 2018, 32(6): 434-441. DOI: 10.7555/JBR.32.20170117
    [5]Huanqiang Wang, Congying Yang, Siyuan Wang, Tian Wang, Jingling Han, Kai Wei, Fucun Liu, Jida Xu, Xianzhen Peng, Jianming Wang. Cell-free plasma hypermethylated CASZ1, CDH13 and ING2 are promising biomarkers of esophageal cancer[J]. The Journal of Biomedical Research, 2018, 32(6): 424-433. DOI: 10.7555/JBR.32.20170065
    [6]Stella Briggs, Uchechukwu L Osuagwu, Essam M AlHarthi. Manifestations of type 2 diabetes in corneal endothelial cell density, corneal thickness and intraocular pressure[J]. The Journal of Biomedical Research, 2016, 30(1): 46-51. DOI: 10.7555/JBR.30.20140075
    [7]Ankit Mahajan, Swarkar Sharma, Manoj K. Dhar, Rameshwar N.K. Bamezai. Risk factors of type 2 diabetes in population of Jammu and Kashmir, India[J]. The Journal of Biomedical Research, 2013, 27(5): 372-379. DOI: 10.7555/JBR.27.20130043
    [8]Ravi Prakash Rao, Ansima Singh, Arun K Jain, Bhartu Parsharthi Srinivasan. Dual therapy of rosiglitazone/pioglitazone with glimepiride on diabetic nephropathy in experimentally induced type 2 diabetes rats[J]. The Journal of Biomedical Research, 2011, 25(6): 411-417. DOI: 10.1016/S1674-8301(11)60054-7
    [9]Juan Du, Hui Shi, Ying Lu, Wencong Du, Yuanyuan Cao, Qian Li, Jianhua Ma, Xinhua Ye, Jinluo Cheng, Xiaofang Yu, Yanqin Gao, Ling Zhou. Tagging single nucleotide polymorphisms in the PPAR-γ and RXR-α gene and type 2 diabetes risk: a case-control study of a Chinese Han population[J]. The Journal of Biomedical Research, 2011, 25(1): 33-41. DOI: 10.1016/S1674-8301(11)60004-3
    [10]Sha Li, Hongguang Bao, Liu Han, Lele Liu. Effects of propofol on early and late cytokines in lipopolysaccharide-induced septic shock in rats[J]. The Journal of Biomedical Research, 2010, 24(5): 389-394. DOI: 10.1016/S1674-8301(10)60052-8

Catalog

    Article Metrics

    Article views (3559) PDF downloads (1152) Cited by()
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return