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Figures of the Article
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Establishment of TP53 KO BEAS-2B cells.
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Loss of p53 leads to remodeling of the enhancer landscape.
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Screening of downstream target genes regulated by p53-dependent super-enhancers (SEs) on chromosomes 5 and 9.
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KLF4-SE is a p53-dependent super enhancer.
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Regulation of KLF4 by KLF4-SE during NNK-induced cell malignant transformation.
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Overexpression of KLF4 reduces cell proliferation and migration in lung cancer cells.
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