Cover: Skeletal muscles are the most abundant tissues in the body and have a remarkable regenerative capacity. Macrophage-mediated inflammatory responses are critical for the recovery of skeletal muscles after ischemia. Wang et al. (pages 23–35) identified scavenger receptor A1 (SR-A1) as a promising candidate molecule for improving tissue repair and regeneration in peripheral ischemic arterial disease, which enhanced skeletal muscle regeneration in a mouse model of hindlimb ischemia by inhibiting oncostatin M (OSM) production through suppression of the NF-κB signaling. In the cover illustration, the hematoxylin and eosin-stained gastrocnemius muscles form the background, with a heavy accumulation of snow symbolizing the presence of OSM, which impedes the regenerative process of skeletal muscles. A shovel, representing the SR-A1, is used to clear the snow, revealing the ground beneath. This cleared surface symbolizes the restoration of healthy gastrocnemius muscle morphology. The image underscores the key role of SR-A1 in promoting skeletal muscle recovery by alleviating the inhibitory effects of OSM. Cover art by Lijuan Zong and Cheng Qian.

2025, 39(1): 23–35. DOI: 10.7555/JBR.38.20240117

CiteScore

Impact Factor

Export File

Citation

Format

Content