Diagnostic and prognostic value of minor elevated cardiac troponin levels for percutaneous coronary intervention-related myocardial injury: a prospective, single-center and double-blind study
This study was supported by the Health Bureau of Jiangsu Province (No. K201104), the Scientific Support Plan of Jiangsu Province (No. BE2011803), the National Natural Science Foundation of China (No. 81170102/H0203), the Priority Academic Program Development of Jiangsu Higher Education Institutions (No. BL2012011), the Fourth Period Project ‘‘333’’ of Jiangsu Province (No. BRA2012207), China.
- Received Date: 2013-08-13
- Publish Date: 2014-03-28
- percutaneous coronary intervention (PCI) /
- troponins /
- PCI-related myocardial injury /
- major adverse cardiac events /
- diagnosis /
Abstract: Cardiac troponin-I (cTnI) and -T (cTnT) are sensitive and specific markers of myocardial injury. However, the role of increased cTnI and cTnT in percutaneous coronary intervention (PCI)-related myocardial injury remains controversial. In this prospective, single-center and double-blind study, we aimed to determine the diagnostic and prognostic value of cTnI as well as cTnT (cTns) in PCI-related myocardial injury in a Chinese population. A total of 1,008 patients with stable angina pectoris and non-ST-segment elevation acute coronary syndrome were recruited. The levels of cTnI and cTnT were examined before and after PCI. All patients were followed up for 26?9 months to observe the incidence of major adverse cardiac events (MACEs). Our results showed that post- PCI cTnI and/or cTnT levels were increased to more than the 99th percentile upper reference limit (URL) in 133 (13.2%) patients, among which 22 (2.2%) were more than 5 6 99th percentile URL. By univariate analysis, an elevation in cTns after PCI was not an independent predictor of increased MACEs, HR 1.35 (P 5 0.33, 95%CI: 0.74-2.46). In conclusion, our data demonstrate that the incidence of PCI-related myocardial injury is not common in a Chinese population and minor elevated cTns levels may not be a sensitive prognostic marker for MACEs.
|Citation:||Min Zhang, Huiwei He, Ze-Mu Wang, Zhihui Xu, Ningtian Zhou, Zhengxian Tao, Bo Chen, Chunjian Li, Tiebing Zhu, Di Yang, Liansheng Wang, Zhijian Yang. Diagnostic and prognostic value of minor elevated cardiac troponin levels for percutaneous coronary intervention-related myocardial injury: a prospective, single-center and double-blind study[J]. The Journal of Biomedical Research, 2014, 28(2): 98-107. doi: 10.7555/JBR.28.20130124|