3.8

CiteScore

2.4

Impact Factor
  • ISSN 1674-8301
  • CN 32-1810/R
Zhengshan Wu, Qingyang Meng, Yongxiang Xia, Feng Zhang, Wei You. A retrospective analysis of the safety and efficacy of low dose tacrolimus (FK506) for living donor liver transplant recipients[J]. The Journal of Biomedical Research, 2013, 27(4): 305-309. DOI: 10.7555/JBR.27.20130023
Citation: Zhengshan Wu, Qingyang Meng, Yongxiang Xia, Feng Zhang, Wei You. A retrospective analysis of the safety and efficacy of low dose tacrolimus (FK506) for living donor liver transplant recipients[J]. The Journal of Biomedical Research, 2013, 27(4): 305-309. DOI: 10.7555/JBR.27.20130023

A retrospective analysis of the safety and efficacy of low dose tacrolimus (FK506) for living donor liver transplant recipients

More Information
  • Received Date: January 13, 2013
  • We sought to evaluate the efficacy and effects of low-dose tacrolimus (FK506) to recipients with living donor liver transplantation (LDLT). A total of 66 patients who underwent LDLT between 2001 and 2007 were enrolled in this study. According to different doses of tacrolimus, the recipients were randomly divided into two groups: the low-dose tacrolimus group (group A) and the normal-dose tacrolimus group (group B). The blood concentra-tion of tacrolimus and its side effects including infection, hyperglycemia, hypertension, high blood creatinine and jaundice were monitored once a week at the perioperative period, and once a month thereafter. Besides, the sur-vival rates of the recipients were analyzed at the 1- and 3-year time point after operation. Among these patients, no significant acute rejection was detected after LDLT. The incidences of infection, hyperglycemia, liver dys-function and renal impairment in group A were markedly lower than those in group B. However, no significant differences were detected in the incidence of hypertension between the two groups. Moreover, the recipients in each group had a similar survival rate according to the results of 1- and 3-year follow-up. The incidence of side effects that associated with tacrolimus positively correlated with tacrolimus blood concentration. In conclusion, long-term and low-dose administration of tacrolimus is a safe and effective treatment for LDLT recipients.
  • Related Articles

    [1]Xiyin Zheng, Lulu Yin, Jing Song, Juan Chen, Wensha Gu, Min Shi, Hong Zhang. ELABELA protects against diabetic kidney disease by activating high glucose-inhibited renal tubular autophagy[J]. The Journal of Biomedical Research, 2023, 37(6): 460-469. DOI: 10.7555/JBR.37.20220214
    [2]Xinlu Chai, Yuting Meng, Wei Ge, Juan Wang, Fei Li, Xue Jun Wang, Xuerong Wang. A novel synthesized prodrug of gemcitabine based on oxygen-free radical sensitivity inhibited the growth of lung cancer cells[J]. The Journal of Biomedical Research, 2023, 37(5): 355-366. DOI: 10.7555/JBR.37.20230022
    [3]Min Shi, Xiangcheng Zhang, Ridong Zhang, Hong Zhang, Dalong Zhu, Xiao Han. Glycyrrhizic acid promotes sciatic nerves recovery in type 1 diabetic rats and protects Schwann cells from high glucose-induced cytotoxicity[J]. The Journal of Biomedical Research, 2022, 36(3): 181-194. DOI: 10.7555/JBR.36.20210198
    [4]Wenqian Xia, Xiao Han, Lin Wang. E26 transformation-specific 1 is implicated in the inhibition of osteogenic differentiation induced by chronic high glucose by directly regulating Runx2 expression[J]. The Journal of Biomedical Research, 2022, 36(1): 39-47. DOI: 10.7555/JBR.35.20210123
    [5]Li Cao, Zhen-zhen Zhang, Shuang-bo Xu, Ming Ma, Xin Wei. Farnesol inhibits development of caries by augmenting oxygen sensitivity and suppressing virulence-associated gene expression in Streptococcus mutans[J]. The Journal of Biomedical Research, 2017, 31(4): 333-343. DOI: 10.7555/JBR.31.20150151
    [6]Zeping Xu, Lianbing Gu, Qingming Bian, Pengyi Li, Lijun Wang, Jingyuan Zhang, Yanning Qian. Oxygenation, inflammatory response and lung injury during one lung ventilation in rabbits using inspired oxygen fraction of 0.6 vs. 1.0[J]. The Journal of Biomedical Research, 2017, 31(1): 56-64. DOI: 10.7555/JBR.31.20160108
    [7]JunLin Cheng, Ying Wang, Zhengwei Zhang, Yong Jin, QianKun Li, RongGen Want, Yan Wang, XiaoKang Li, Qiang Xiong, ManLing Zhang, RongFeng Li, YiFan Dai. Dominant-negative inhibition of glucose-dependent insulinotropic polypeptide impairs function of b cells in transgenic pigs[J]. The Journal of Biomedical Research, 2015, 29(6): 512-514. DOI: 10.7555/JBR.29.20150046
    [8]Xiaodong Yang, Ping Huang, Feng Wang, Zekuan Xu, Xiaonin Wang. Growth hormone receptor expression in human primary gastric adenocarcinoma[J]. The Journal of Biomedical Research, 2012, 26(5): 307-314. DOI: 10.7555/JBR.26.20110133
    [9]Yumin Zhang, Gerard B. Fox. PET imaging for receptor occupancy: meditations on calculation and simplification[J]. The Journal of Biomedical Research, 2012, 26(2): 69-76. DOI: 10.1016/S1674-8301(12)60014-1
    [10]Keh-Dong Shiang, Fouad Kandeel. A computational model of the human glucose-insulin regulatory system[J]. The Journal of Biomedical Research, 2010, 24(5): 347-364. DOI: 10.1016/S1674-8301(10)60048-6

Catalog

    Wei You

    1. On this Site
    2. On Google Scholar
    3. On PubMed

    Article Metrics

    Article views (4476) PDF downloads (965) Cited by()
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return