• ISSN 1674-8301
  • CN 32-1810/R
Volume 27 Issue 4
Jul.  2013
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Article Contents
Naveen Kumar Mekala, Rama Raju Baadhe, Sreenivasa Rao Parcha, Prameela Devi Yalavarthy. Physical and degradation properties of PLGA scaffolds fabricated by salt fusion technique[J]. The Journal of Biomedical Research, 2013, 27(4): 318-325. doi: 10.7555/JBR.27.20130001
Citation: Naveen Kumar Mekala, Rama Raju Baadhe, Sreenivasa Rao Parcha, Prameela Devi Yalavarthy. Physical and degradation properties of PLGA scaffolds fabricated by salt fusion technique[J]. The Journal of Biomedical Research, 2013, 27(4): 318-325. doi: 10.7555/JBR.27.20130001

Physical and degradation properties of PLGA scaffolds fabricated by salt fusion technique

doi: 10.7555/JBR.27.20130001
  • Received: 2013-01-04
  • Issue Date: 2013-07-28
  • Tissue engineering scaffolds require a controlled pore size and interconnected pore structures to support the host tissue growth. In the present study, three dimensional (3D) hybrid scaffolds of poly lactic acid (PLA) and poly glycolic acid (PGA) were fabricated using solvent casting/particulate leaching. In this case, partially fused NaCl particles were used as porogen (200-300μ) to improve the overall porosity ( ≥ 90%) and internal texture of scaffolds. Differential scanning calorimeter (DSC) analysis of these porous scaffolds revealed a gradual reduc-tion in glass transition temperature (Tg) (from 48°C to 42.5°C) with increase in hydrophilic PGA content. The potential applications of these scaffolds as implants were further tested for their biocompatibility and biodegrad-ability in four simulated body fluid (SBF) types in vitro. Whereas, simulated body fluid (SBF) Type1 with the op-timal amount of HCO3- ions was found to be more appropriate and sensible for testing the bioactivity of scaffolds. Among three combinations of polymer scaffolds, sample B with a ratio of 75:25 of PLA: PGA showed greater stability in body fluids (pH 7.2) with an optimum degradation rate (9% to 12% approx). X-ray diffractogram also confirmed a thin layer of hydroxyapatite deposition over sample B with all SBF types in vitro.

     

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