4.6

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2.2

Impact Factor
  • ISSN 1674-8301
  • CN 32-1810/R
Yuetong Chen, Chen Li, Yi Shi, Jiali Dai, Yixuan Meng, Shuwei Li, Cuiju Tang, Dongying Gu, Jinfei Chen. Identification of common genetic variants in KCNQ family genes associated with gastric cancer survival in a Chinese population[J]. The Journal of Biomedical Research. DOI: 10.7555/JBR.38.20240040
Citation: Yuetong Chen, Chen Li, Yi Shi, Jiali Dai, Yixuan Meng, Shuwei Li, Cuiju Tang, Dongying Gu, Jinfei Chen. Identification of common genetic variants in KCNQ family genes associated with gastric cancer survival in a Chinese population[J]. The Journal of Biomedical Research. DOI: 10.7555/JBR.38.20240040

Identification of common genetic variants in KCNQ family genes associated with gastric cancer survival in a Chinese population

  • KCNQ family genes (KCNQ1-5), encoding voltage-gated K+ (Kv) channels, have been revealed to have potential pathophysiological roles in cancers. However, the associations between genetic variants located in KCNQ family genes and gastric cancer survival remain unclear. A large-scale cohort comprising 1,135 Chinese gastric cancer patients was enrolled to identify genetic variants in KCNQ family genes associated with overall survival (OS). Based on the survival evaluation of all five members, KCNQ1 was selected for subsequent genetic analysis. Cox regression models and stepwise Cox regression models were conducted to evaluate survival-related genetic variants. We found that KCNQ1 rs10832417 was associated with increased OS in gastric cancer patients (adjusted hazard ratio (HR) = 0.84, 95% confidence interval (CI): 0.72–0.98, P = 0.023). Subsequently, a nomogram was generated to support the prognostic capacity and clinical translation of rs10832417 variants. The rs10832417 T allele was predicted to increase the minimum free energy (MFE) of the secondary structure. Furthermore, we observed that gastric cancer patients with downregulation of KCNQ1 had poor survival in multiple public datasets. The present study found that KCNQ1 rs10832417 could serve as an independent prognostic predictor of gastric cancer, yielding novel insight into the progression and survival of gastric cancer.
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