Mast cell activation syndrome—anesthetic challenges in two different clinical scenarios

Brianna Lide; Shane McGuire; Hong Liu; Cristina Chandler

doi:10.7555/JBR.36.20220071

Volume 36 Issue 6

Nov. 2022

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The Journal of Biomedical Research > 2022 > 36(6): 435-439. > DOI: 10.7555/JBR.36.20220071

Brianna Lide, Shane McGuire, Hong Liu, Cristina Chandler. Mast cell activation syndrome—anesthetic challenges in two different clinical scenarios[J]. The Journal of Biomedical Research, 2022, 36(6): 435-439. DOI: 10.7555/JBR.36.20220071

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Mast cell activation syndrome—anesthetic challenges in two different clinical scenarios

Department of Anesthesiology and Pain Medicine, University of California Davis Health, Sacramento, CA 95817, USA

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Corresponding author:
Cristina Chandler and Hong Liu, Department of Anesthesiology and Pain Medicine, University of California Davis Health, 4150 V Street, Suite 1200, Sacramento, CA 95817, USA. Tel/Fax: +1-916-734-5031/+1-916-734-7980, E-mails: cmchandler@ucdavis.edu and hualiu@ucdavis.edu
Received Date: April 01, 2022
Revised Date: April 24, 2022
Accepted Date: April 27, 2022
Available Online: May 27, 2022

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Abstract

Abstract

Mast cell activation syndrome (MCAS) includes a group of disorders that result in the inappropriate release of inflammatory mediators from mast cells. These mediators can affect multiple organ systems and lead to significant morbidity, and possible fatality. Although reactions, typically in response to various nonspecific stimuli, are usually mild, they may put those with MCAS at increased risk of anaphylaxis. In this case report, we present two clinical scenarios of MCAS, and identify possible factors triggering mast cell mediator release. We also define a preoperative preventive pathway, outline anesthetic considerations, and discuss the management of immediate hypersensitivity reactions in patients with MCAS. Meticulous preoperative preparation, avoidance of triggers, and development of a plan to treat possible adverse organ responses are paramount of good outcomes.
- mast cell disease,
- mast cell activation syndrome

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Acknowledgments

This work was supported in part by the Department of Anesthesiology and Pain Medicine of University of California Davis Health and NIH grant UL1 TR000002 to the University of California Davis Health.

CLC number: R614, Document code: B

The authors reported no conflict of interests.

References (10)

References

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Mast cell activation syndrome—anesthetic challenges in two different clinical scenarios

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