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Jie Wen, Tingyu Pan, Hongyan Li, Fei Chen, Zhiyou Cai, Bin Zhao. Role of mitophagy in the hallmarks of aging Running title: Mitophagy in aging[J]. The Journal of Biomedical Research. doi: 10.7555/JBR.36.20220045
Citation: Jie Wen, Tingyu Pan, Hongyan Li, Fei Chen, Zhiyou Cai, Bin Zhao. Role of mitophagy in the hallmarks of aging Running title: Mitophagy in aging[J]. The Journal of Biomedical Research. doi: 10.7555/JBR.36.20220045

Role of mitophagy in the hallmarks of aging Running title: Mitophagy in aging

doi: 10.7555/JBR.36.20220045
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  • Corresponding author: Zhiyou Cai, Department of Neurology, Chongqing General Hospital, 312 Zhongshan First Road, Yuzhong District, Chongqing 400013, China. Tel/Fax: +86-23-63515796/+86-23-63515796, E-mail: caizhiyou@ucas.ac.cn; Bin Zhao, Department and Institute of Neurology, Guangdong Medical University, Guangdong Key Laboratory of Aging-related Cardiac and Cerebral Diseases, 57 Renmin Road, Zhanjiang, Guangdong 524001, China. Tel/Fax: +86-759-2386949/+86-13-902501596, E-mail: binzhaoe@gdmu.edu.cn/binzhaoe@163.com
  • Received: 2022-03-10
  • Revised: 2022-06-10
  • Accepted: 2022-06-27
  • Published: 2022-08-28
  • Aging, subjected to scientific scrutiny, is extensively defined as a time-dependent decline in function that involves the majority of organisms. The time-dependent accretion of cellular lesions is generally a universal trigger of aging. Mitochondrial dysfunction is a sign of aging. Dysfunctional mitochondria are identified and removed by mitophagy, a selective form of macroautophagy. Increased mitochondrial damage resulting from reduced biogenesis and clearance may promote the aging process. The primary purpose of this paper is to illustrate in detail the effect of mitophagy on aging and emphasize on the association between mitophagy and other signs of aging including dietary restriction, telomere shortening, epigenetic alterations, and protein imbalance. The evidence regarding the effect of these relationships on aging is still limited, and although the relationship between mitophagy and aging has been long-awaited, analyzing of its details remains the main challenge in aging studies.


  • CLC number: R363,, Document code: A
    The authors reported no conflict of interests.
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