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  • CN 32-1810/R
Volume 36 Issue 5
Sep.  2022
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Hui Li, Yang Chen, Jianqin Niu, Chenju Yi. New insights into the immunologic role of oligodendrocyte lineage cells in demyelination diseases[J]. The Journal of Biomedical Research, 2022, 36(5): 343-352. doi: 10.7555/JBR.36.20220016
Citation: Hui Li, Yang Chen, Jianqin Niu, Chenju Yi. New insights into the immunologic role of oligodendrocyte lineage cells in demyelination diseases[J]. The Journal of Biomedical Research, 2022, 36(5): 343-352. doi: 10.7555/JBR.36.20220016

New insights into the immunologic role of oligodendrocyte lineage cells in demyelination diseases

doi: 10.7555/JBR.36.20220016
Funds:  This work was supported by research grants from Shenzhen Fundamental Research Program (Grants No. RCYX20200714114644167, JCYJ20190809161405495, and JCYJ20210324123212035), National Natural Science Foundation of China (Grants No. 81971309, 32170980, and 32070964), and Guangdong Basic and Applied Basic Research Foundation (Grants No. 2019A1515011333 and 2022B1515020012).
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  • Corresponding author: Jianqin Niu, Department of Histology and Embryology, Chongqing Key Laboratory of Neurobiology, Brain and Intelligence Research Key Laboratory of Chongqing Education Commission, Third Military Medical University, Gaotanyan Main street, Chongqing 400038, China. Tel: +86-13668016001, E-mail: jianqinniu@163.com; Chenju Yi, Research Centre, the Seventh Affiliated Hospital of Sun Yat-sen University, 628 Zhenyuan Road, Guangming (New) District, Shenzhen 518107, China. Tel: +86-13419189905, E-mail: yichj@mail.sysu.edu.cn
  • Received: 2022-01-21
  • Revised: 2022-02-16
  • Accepted: 2022-03-09
  • Published: 2022-04-28
  • Issue Date: 2022-09-28
  • Oligodendrocyte lineage cells (OL-lineage cells) are a cell population that are crucial for mammalian central nervous system (CNS) myelination. OL-lineage cells go through developmental stages, initially differentiating into oligodendrocyte precursor cells (OPCs), before becoming immature oligodendrocytes, then mature oligodendrocytes (OLs). While the main function of cell lineage is in myelin formation, and increasing number of studies have turned to explore the immunological characteristics of these cells. Initially, these studies focused on discovering how OPCs and OLs are affected by the immune system, and then, how these immunological changes influence the myelination process. However, recent studies have uncovered another feature of OL-lineage cells in our immune systems. It would appear that OL-lineage cells also express immunological factors such as cytokines and chemokines in response to immune activation, and the expression of these factors changes under various pathologic conditions. Evidence suggests that OL-lineage cells actually modulate immune functions. Indeed, OL-lineage cells appear to play both "victim" and "agent" in the CNS which raises a number of questions. Here, we summarize immunologic changes in OL-lineage cells and their effects, as well as consider OL-lineage cell changes which influence immune cells under pathological conditions. We also describe some of the underlying mechanisms of these changes and their effects. Finally, we describe several studies which use OL-lineage cells as immunotherapeutic targets for demyelination diseases.


  • CLC number: R741.02, Document code: A
    The authors reported no conflict of interests.
    These authors contributed equally to this work.
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