• ISSN 1674-8301
  • CN 32-1810/R
Volume 35 Issue 6
Nov.  2021
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Xintong Zhang, Yu Zheng, Canru Geng, Juntao Guan, Lu Wang, Xiu Zhang, Yihui Cheng, Jian'an Li, Xiao Lu. Isometric exercise promotes arteriogenesis in rats after myocardial infarction[J]. The Journal of Biomedical Research, 2021, 35(6): 436-447. doi: 10.7555/JBR.35.20210062
Citation: Xintong Zhang, Yu Zheng, Canru Geng, Juntao Guan, Lu Wang, Xiu Zhang, Yihui Cheng, Jian'an Li, Xiao Lu. Isometric exercise promotes arteriogenesis in rats after myocardial infarction[J]. The Journal of Biomedical Research, 2021, 35(6): 436-447. doi: 10.7555/JBR.35.20210062

Isometric exercise promotes arteriogenesis in rats after myocardial infarction

doi: 10.7555/JBR.35.20210062
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  • Corresponding author: Xiao Lu and Jian'an Li, Department of Rehabilitation Medicine, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, China. Tel: +86-25-68303156. E-mails: luxiao1972@163.com and lijianan@carm.org.cn; 
  • Received: 2021-04-12
  • Revised: 2021-05-23
  • Accepted: 2021-05-25
  • Published: 2021-07-30
  • Issue Date: 2021-11-28
  • Isometric exercise (IE) is a promising intervention of noninvasive revascularization in patients with acute myocardial infarction (AMI). This study aimed to investigate the impact and mechanisms of IE training on arteriogenesis in AMI. Male Sprague-Dawley rats were randomly assigned into the sham-operation group (SO), myocardial infarction (MI) group, and 13 IE subgroups treated according to training intensity, frequency, duration, or monocyte chemoattractant protein-1 (MCP-1), or/and fibroblast growth factor-2 (FGF-2) inhibitors for eight weeks. Our results demonstrated that the IE group achieved superior improvement compared with the MI group in terms of left ventricular ejection fraction (LVEF), myocardial infarction size (MIS), arterial density (AD), monocytes (MNCs), smooth muscle cells (SMCs), endothelial cells (ECs), relative collateral blood flow (RCBF), MCP-1, and FGF-2 at the endpoint. Positive correlations between MCP-1 and MNCs, MNCs and FGF-2, FGF-2 and SMCs, SMCs and AD, as well as AD and RCBF were observed. This study demonstrated that with MI of 100% load 20 times daily for eight weeks, the arteriogenesis was improved, which may be attributed to the recruitment of MNCs and SMCs in remote ischemic myocardium caused by increases in MCP-1 and FGF-2 expression.

     

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