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Nan N. Jiang, Ramiro Larrazabal, Waleed Alsunbul, Jian-Qiang Lu. Multiple pathological components in gliosarcoma[J]. The Journal of Biomedical Research. doi: 10.7555/JBR.34.20200089
Citation: Nan N. Jiang, Ramiro Larrazabal, Waleed Alsunbul, Jian-Qiang Lu. Multiple pathological components in gliosarcoma[J]. The Journal of Biomedical Research. doi: 10.7555/JBR.34.20200089

Multiple pathological components in gliosarcoma

doi: 10.7555/JBR.34.20200089
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  • Corresponding author: Nan N. Jiang, Department of Diagnostic Radiology, Hamilton General Hospital, McMaster University, 237 Barton St. E, Hamilton, Ontario L8L 2X2, Canada. Tel: +1-905-527-4322 ext. 46521, E-mail: nan.jiang@medportal.ca
  • Received: 08 June 2020
  • Accepted: 23 July 2020
  • Published: 25 September 2020
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  • [1] Jiang N, Larrazabal R, Alsunbul W, et al. Angiosarcomatous component in gliosarcoma: case report and consideration of diagnostic challenge and hemorrhagic propensity[J]. J Biomed Res, 2020, 34(2): 143–148. doi:  10.7555/JBR.33.20190080
    [2] Perry A, Miller CR, Gujrati M, et al. Malignant gliomas with primitive neuroectodermal tumor-like components: a clinicopathologic and genetic study of 53 cases[J]. Brain Pathol, 2009, 19(1): 81–90. doi:  10.1111/j.1750-3639.2008.00167.x
    [3] Ali S, Joseph NM, Perry A, et al. Apparent diffusion coefficient in glioblastoma with PNET-like components, a GBM variant[J]. J Neurooncol, 2014, 119(2): 353–360. doi:  10.1007/s11060-014-1485-3
    [4] Louis DN, Ohgaki H, Wiestler OD, et al. World health organization histological classification of tumours of the central nervous system[M]. 4th ed. Lyon: International Agency for Research on Cancer, 2016: 28–49.
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Multiple pathological components in gliosarcoma

doi: 10.7555/JBR.34.20200089
    Corresponding author: Nan N. Jiang, Department of Diagnostic Radiology, Hamilton General Hospital, McMaster University, 237 Barton St. E, Hamilton, Ontario L8L 2X2, Canada. Tel: +1-905-527-4322 ext. 46521, E-mail: nan.jiang@medportal.ca
Nan N. Jiang, Ramiro Larrazabal, Waleed Alsunbul, Jian-Qiang Lu. Multiple pathological components in gliosarcoma[J]. The Journal of Biomedical Research. doi: 10.7555/JBR.34.20200089
Citation: Nan N. Jiang, Ramiro Larrazabal, Waleed Alsunbul, Jian-Qiang Lu. Multiple pathological components in gliosarcoma[J]. The Journal of Biomedical Research. doi: 10.7555/JBR.34.20200089
  • Dear Editor:

    Our recent article "Angiosarcomatous component in Glioblastoma: case report and consideration of diagnostic challenge and hemorrhagic propensity" published in The Journal of Biomedical Research[1] demonstrated an interesting case of gliosarcoma with alternating gliomatous and angiosarcomatous components, which on imaging, displayed unique intratumorally piliform enhancement pattern and clinically, exhibited an increased tendency for intraoperative hemorrhage. Indeed, gliosarcoma may be composed of various different pathological components and may dictate the radiological features and clinical presentations that make preoperative diagnosis extremely difficult.

    We have noted that gliosarcomas may contain not only angiosarcomatous but also other unusual sarcomatous components to varying degrees (in addition of the defining gliomatous component). A primitive neuronal component is occasionally seen in glioblastoma, which is traditionally described as primitive neuroectodermal tumor (PNET)-like components[2-3]; a component of giant cell glioblastoma/variant is not usually found in gliosarcoma[4]. The coexistence of these pathological components within a brain tumor has not been reported in the literature. Here we described a case of gliosarcoma containing multiple pathological components. The patient was a 77-year-old male presented with a 4-month history of progressive right facial palsy, left-sided weakness and memory loss. Brain computed tomography and magnetic resonance (MR) imaging showed a 6.8 cm peripherally-located well circumscribed, mixed solid and cystic mass centered in the right temporal lobe with peritumoral edema (Fig. 1). The mass displayed an irregular thick wall with a large nodular component that has a bubbly appearance. On MR imaging, the mass was hypointense on T1-weighted sequence and intermediate on T2-weighted sequence. The wall and nodular components of this mass demonstrated both heterogeneous enhancement and restricted diffusion. In contrast to the published case of glioblastoma with angiosarcomatous component1, this mass exhibited no piliform enhancement pattern on imaging.

    Figure 1.  Preoperative neuroimaging.

    Intraoperatively, the mass is relatively well-circumscribed and did not display an increased hemorrhagic tendency during the surgery as compared to our previously reported gliosarcoma with angiomatous features. On pathological examination of the resected tissue, the tumor exhibited multiple components including largely alternating gliomatous and sarcomatous features with a focally abundant giant cells intermixed with primitive neuronal features (Fig. 2). The tumor exhibited positive p53 immunostaining in the gliomatous component and negative IDH1(R132H) immunostaining, along with necrosis, microvascular proliferation, and mitotic activity with a high Ki-67 proliferation index (focally more than 90%). These pathological features were diagnostic of a glioblastoma variant consistent with gliosarcoma.

    Figure 2.  Photomicrographs of a glioblastoma variant with multiple components.

    In contrast to our recently published case, this example illustrates the multitude of pathological variations in gliosarcoma with variably complex neuroimaging patterns. Therefore, the key is to be cognizant of the various glioblastoma variants/gliosarcomas and their possible neuroimaging features in order to aid preoperative diagnosis and surgical management.

    Yours Sincerely,Nan N. Jiang1,✉, Ramiro Larrazabal1, Waleed Alsunbul2, Jian-Qiang Lu31 Department of Radiology,2 Department of Surgery/Neurosurgery,3 Department of Pathology and Molecular Medicine/Neuropathology, McMaster University, Hamilton, Ontario L8L 2X2, Canada.Tel: +1-905-527-4322 ext. 46521, E-mail: nan.jiang@medportal.ca.

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