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  • ISSN 1674-8301
  • CN 32-1810/R
Volume 31 Issue 3
Apr.  2017
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Xu Hu, Linfei Jiang, Chenhui Tang, Yuehong Ju, Li Jiu, Yongyue Wei, Li Guo, Yang Zhao. Association of three single nucleotide polymorphisms of ESR1 with breast cancer susceptibility: a meta-analysis[J]. The Journal of Biomedical Research, 2017, 31(3): 213-225. DOI: 10.7555/JBR.31.20160087
Citation: Xu Hu, Linfei Jiang, Chenhui Tang, Yuehong Ju, Li Jiu, Yongyue Wei, Li Guo, Yang Zhao. Association of three single nucleotide polymorphisms of ESR1 with breast cancer susceptibility: a meta-analysis[J]. The Journal of Biomedical Research, 2017, 31(3): 213-225. DOI: 10.7555/JBR.31.20160087
shu

Association of three single nucleotide polymorphisms of ESR1 with breast cancer susceptibility: a meta-analysis

  • 1.

    Department of Biotechnology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu 211166, China

  • 2.

    School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, Jiangsu 211198, China

  • 3.

    Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China

  • 4.

    School of Geographic and Biologic Information, Nanjing University of Posts and Telecommunications, Nanjing, Jiangsu 210046, China

Funds: 

This work was supported by the National Natural Science Foundation of China (No. 81373102 to YZ, No. 61301251 to LG)

the Natural Science Foundation of the Jiangsu Higher Education Institutions of China (No. 12KJB310003)

Priority Academic Program Development of Jiangsu Higher Education Institution (PAPD)

and Flagship Major Development of Jiangsu Higher Education Institutions. This study is also supported by the Qing-lan Project of Jiangsu Province and the Excellent Young Teach Project of Nanjing Medical University. Xu Hu contributed to data analysis and manuscript preparation. Linfei Jiang, Chenhui Tang, Yuehong Ju and Li Jiu also performed data analysis and prepared the manuscript. Li Jiu helped polish the language of the manuscript. Yongyue Wei and Li Guo helped perform analysis and contributed constructive discussions. Yang Zhao contributed to the conception and design of the study. The final version was approved by all the above authors.

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  • Received Date: July 22, 2016
  • Revised Date: September 24, 2016
    Graphical Abstract
    • Abstract
  • Expression of estrogen receptors is correlated with breast cancer risk, but inconsistent results have been reported. To clarify potential estrogen receptor (ESR)-related breast cancer risk, we analyzed genetic variants of ESR1 in association with breast cancer susceptibility. We performed a meta-analysis to investigate the association between rs2234693, rs1801132, and rs2046210 (single nucleotide polymorphisms of ESR1), and breast cancer risk. Our analysis included 44 case-control studies. For rs2234693, the CC genotype had a higher risk of breast cancer compared to the TT or CT genotype. For rs2046210, the AA, GA, or GA + GG genotype had a much higher risk compared to the GG genotype. No significant association was found for the rs1801132 polymorphism with breast cancer risk. This meta-analysis demonstrates association between the rs2234693 and rs2046210 polymorphisms of ESR1 and breast cancer risk. The correlation strength between rs2234693 and breast cancer susceptibility differs in subgroup assessment by ethnicity.
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    1. Aktaş G, Bertizlioglu M, Yılmaz SA, et al. Follicle-Stimulating Hormone Receptor and Estrogen Receptor Gene Polymorphisms in Women With Discordant Follicle-Stimulating Hormone and Anti-Mullerian Hormone Levels. Cureus, 2024, 16(5): e60446. DOI:10.7759/cureus.60446
    2. Miedl H, Oswald D, Haslinger I, et al. Association of the Estrogen Receptor 1 Polymorphisms rs2046210 and rs9383590 with the Risk, Age at Onset and Prognosis of Breast Cancer. Cells, 2023, 12(4): 515. DOI:10.3390/cells12040515
    3. Khorshid Shamshiri A, Alidoust M, Hemmati Nokandei M, et al. Genetic architecture of mammographic density as a risk factor for breast cancer: a systematic review. Clin Transl Oncol, 2023, 25(6): 1729-1747. DOI:10.1007/s12094-022-03071-8
    4. Allahloubi NMA, Zekri AN, Ragab M, et al. Estrogen Receptor Gene Polymorphism as a Possible Genetic Risk Factor for Treatment Response in ER-Positive Breast Cancer Patients. Biochem Genet, 2022, 60(6): 1963-1985. DOI:10.1007/s10528-022-10199-3
    5. Kasielska-Trojan A, Pietrusiński M, Bugaj-Tobiasz M, et al. Genetic Factors of Idiopathic Gigantomastia: Clinical Implications of Aromatase and Progesterone Receptor Polymorphisms. J Clin Med, 2022, 11(3): 642. DOI:10.3390/jcm11030642
    6. Karsono R, Haryono SJ, Karsono B, et al. ESR1 PvuII polymorphism: from risk factor to prognostic and predictive factor of the success of primary systemic therapy in advanced breast cancer. BMC Cancer, 2021, 21(1): 1348. DOI:10.1186/s12885-021-09083-x
    7. Tan SC, Low TY, Mohamad Hanif EA, et al. The rs9340799 polymorphism of the estrogen receptor alpha (ESR1) gene and its association with breast cancer susceptibility. Sci Rep, 2021, 11(1): 18619. DOI:10.1038/s41598-021-97935-8
    8. Lukina SS, Burdennyy AM, Zavarykina TM, et al. The Role of ESR1 Gene Polymorphic Markers in the Development of Breast Cancer and Resistance to Tamoxifen Therapy. Bull Exp Biol Med, 2021, 170(3): 350-355. DOI:10.1007/s10517-021-05065-y
    9. Al-Amri RJ, Alotibi MKH, Al-Raddadi RI, et al. Estrogen Receptor 1 Gene (ESR1) rs2234693 Polymorphism and Breast Cancer Risk in Saudi Women. Asian Pac J Cancer Prev, 2020, 21(11): 3235-3240. DOI:10.31557/APJCP.2020.21.11.3235
    10. Sartor H, Brandt J, Grassmann F, et al. The association of single nucleotide polymorphisms (SNPs) with breast density and breast cancer survival: the Malmö Diet and Cancer Study. Acta Radiol, 2020, 61(10): 1326-1334. DOI:10.1177/0284185119900436
    11. Kasielska-Trojan A, Danilewicz M, Strużyna J, et al. The role of oestrogen and progesterone receptors in gigantomastia. Arch Med Sci, 2019, 18(4): 1016-1020. DOI:10.5114/aoms.2019.88280
    12. Al-Eitan LN, Rababa'h DM, Alghamdi MA, et al. Association between ESR1, ESR2, HER2, UGT1A4, and UGT2B7 polymorphisms and breast Cancer in Jordan: a case-control study. BMC Cancer, 2019, 19(1): 1257. DOI:10.1186/s12885-019-6490-7
    13. Pinkas J, Bojar I, Gujski M, et al. Effect of interactions between APOE and ESR1 polymorphisms on cognitive functions in postmenopausal women. Arch Med Sci, 2018, 17(1): 31-39. DOI:10.5114/aoms.2018.72972
    14. Pontin PA, Nogara PRB, Fonseca FCP, et al. ERα PvuII and XbaI polymorphisms in postmenopausal women with posterior tibial tendon dysfunction: a case control study. J Orthop Surg Res, 2018, 13(1): 316. DOI:10.1186/s13018-018-1020-x
    15. Zhang ZL, Zhang CZ, Li Y, et al. Association between ERα gene Pvu II polymorphism and breast cancer susceptibility: A meta-analysis. Medicine (Baltimore), 2018, 97(17): e0317. DOI:10.1097/MD.0000000000010317

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