4.6

CiteScore

2.2

Impact Factor
  • ISSN 1674-8301
  • CN 32-1810/R
Lei Wang, Sixin Sun, Lei Yang, Chun Lu, Xiaojian Cao. Effects of leptin on femoral fracture in rats[J]. The Journal of Biomedical Research, 2018, 32(2): 130-135. DOI: 10.7555/JBR.31.20160077
Citation: Lei Wang, Sixin Sun, Lei Yang, Chun Lu, Xiaojian Cao. Effects of leptin on femoral fracture in rats[J]. The Journal of Biomedical Research, 2018, 32(2): 130-135. DOI: 10.7555/JBR.31.20160077

Effects of leptin on femoral fracture in rats

More Information
  • Received Date: June 27, 2016
  • Revised Date: August 14, 2016
  • In this study, our objective was to evaluate effects of leptin on fracture healing in rats. Seventy two male SpragueDawley (SD) rats were randomized into 3 groups. Standardized femoral fractures were created in all the rats. Group A was treated with 1 mL normal saline (NS), group B with 0.3 μg/kg leptin in 1 mL NS, and group C with 0.5 μg/kg leptin in 1 mL NS for 2 weeks intraperitoneally. Each group was divided into three subgroups including 8 rats for evaluation at 2, 4 and 8 weeks. Radiological evaluation showed that callus formation of group B and C was all significantly higher than group A at 8 weeks (P = 0.04 and P = 0.013, respectively). There was no statistically significant difference in fracture healing between group B and group C at 8 weeks (P = 0.197). Histological evaluation revealed fracture healing of group B and C was better than group A at 4 weeks (P = 0.01 and P = 0.002, respectively) and 8 weeks (P = 0.008 and P = 0.003, respectively). Micro-computed tomography (Micro-CT) analysis demonstrated that greater amounts of bony callus and evidence of bone fusion were observed in group B and C at 4 weeks (P = 0.02 and P = 0.04, respectively) and 8 weeks (P = 0.005 and P = 0.001, respectively) compared to group A. Group C also had better fracture healing than group B at 8 weeks (P = 0.01). In conclusion, leptin has a positive effect on rat femoral fracture healing.
  • Related Articles

    [1]Kang Jin Seok. Effects of methotrexate on collagen-induced arthritis in male Wistar rats[J]. The Journal of Biomedical Research, 2019, 33(4): 244-249. DOI: 10.7555/JBR.32.20170019
    [2]Kaibo Lin, Shikun Zhang, Jieli Chen, Ding Yang, Mengyi Zhu, Eugene Yujun Xu. Generation and functional characterization of a conditional Pumilio2 null allele[J]. The Journal of Biomedical Research, 2018, 32(6): 434-441. DOI: 10.7555/JBR.32.20170117
    [3]Fengzhen Wang, Mingwan Zhang, Dongsheng Zhang, Yuan Huang, Li Chen, Sunmin Jiang, Kun Shi, Rui Li. Preparation, optimization, and characterization of chitosancoated solid lipid nanoparticles for ocular drug delivery[J]. The Journal of Biomedical Research, 2018, 32(6): 411-423. DOI: 10.7555/JBR.32.20160170
    [4]Christopher J. Danford, Zemin Yao, Z. Gordon Jiang. Non-alcoholic fatty liver disease: a narrative review of genetics[J]. The Journal of Biomedical Research, 2018, 32(6): 389-400. DOI: 10.7555/JBR.32.20180045
    [5]Arjang Ahmadpour, Amir Goodarzi, Darrin J. Lee, Ripul R. Panchal, Kee D. Kim. Cervical spine fractures in osteopetrosis: a case report and review of the literature[J]. The Journal of Biomedical Research, 2018, 32(1): 68-76. DOI: 10.7555/JBR.32.20170055
    [6]Leijian Guan, Kaixuan Xu, Shuyang Xu, Ningning Li, Xinru Wang, Yankai Xia, Di Wu. Profiles of metabolic gene expression in the white adipose tissue, liver and hypothalamus in leptin knockout (LepΔI14/ΔI14 ) rats[J]. The Journal of Biomedical Research, 2017, 31(6): 528-540. DOI: 10.7555/JBR.31.20170021
    [7]Alireza Shirpoor, Farzaneh Hosseini Gharalari, Yousef Rasmi, Elaheh Heshmati. Ginger extract attenuates ethanol-induced pulmonary histological changes and oxidative stress in rats[J]. The Journal of Biomedical Research, 2017, 31(6): 521-527. DOI: 10.7555/JBR.31.20160151
    [8]Qingqing Li, Long Xiao, Jianwei Zhang, Jin Fan, Wei Zhou, Guoyong Yin, Yongxin Ren. The impact of endplate fracture on postoperative vertebral height loss and kyphotic deformity during treatment of osteoporotic vertebral compression fractures with balloon kyphoplasty[J]. The Journal of Biomedical Research, 2016, 30(5): 419-426. DOI: 10.7555/JBR.30.20150071
    [9]Xiaoyu Chen, Jieyu Bian, Yingbin Ge. Zinc-deficient diet aggravates ventilation-induced lung injury in rats[J]. The Journal of Biomedical Research, 2012, 26(1): 59-65. DOI: 10.1016/S1674-8301(12)60008-6
    [10]Ibrahim M. Hamouda, Salah H. Shehata. Fracture resistance of posterior teeth restored with modern restorative materials[J]. The Journal of Biomedical Research, 2011, 25(6): 418-424. DOI: 10.1016/S1674-8301(11)60055-9
  • Cited by

    Periodical cited type(4)

    1. De la Cruz-Color L, Dominguez-Rosales JA, Maldonado-González M, et al. Evidence That Peripheral Leptin Resistance in Omental Adipose Tissue and Liver Correlates with MASLD in Humans. Int J Mol Sci, 2024, 25(12): 6420. DOI:10.3390/ijms25126420
    2. Casado ME, Collado-Pérez R, Frago LM, et al. Recent Advances in the Knowledge of the Mechanisms of Leptin Physiology and Actions in Neurological and Metabolic Pathologies. Int J Mol Sci, 2023, 24(2): 1422. DOI:10.3390/ijms24021422
    3. Chenouard V, Remy S, Tesson L, et al. Advances in Genome Editing and Application to the Generation of Genetically Modified Rat Models. Front Genet, 2021, 12: 615491. DOI:10.3389/fgene.2021.615491
    4. Lin SY, Yang CP, Wang YY, et al. Interleukin-4 Improves Metabolic Abnormalities in Leptin-Deficient and High-Fat Diet Mice. Int J Mol Sci, 2020, 21(12): 4451. DOI:10.3390/ijms21124451

    Other cited types(0)

Catalog

    Article Metrics

    Article views (3133) PDF downloads (122) Cited by(4)
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return