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  • ISSN 1674-8301
  • CN 32-1810/R
Volume 29 Issue 2
Feb.  2015
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Oluyomi S. Adeyemi, Faoziyat A. Sulaiman. Evaluation of metal nanoparticles for drug delivery systems[J]. The Journal of Biomedical Research, 2015, 29(2): 145-149. DOI: 10.7555/JBR.28.20130096
Citation: Oluyomi S. Adeyemi, Faoziyat A. Sulaiman. Evaluation of metal nanoparticles for drug delivery systems[J]. The Journal of Biomedical Research, 2015, 29(2): 145-149. DOI: 10.7555/JBR.28.20130096
shu

Evaluation of metal nanoparticles for drug delivery systems

  • 1.

    Department of Biological Sciences, Landmark University, Omu-Aran, Kwara State, Nigeria

  • 2.

    Department of Biochemistry, University of Ilorin, Ilorin, Nigeria

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  • Received Date: June 23, 2013
  • Revised Date: July 14, 2013
    Graphical Abstract
    • Abstract
  • Diminazene aceturate is a trypanocide with unwanted toxicity and limited efficacy. It was reasoned that conjugating diminazene aceturate to functionalized nanoparticle would lower untoward toxicity while improving selectivity and therapeutic efficacy. Silver and gold nanoparticles were evaluated for their capacities to serve as carriers for diminazene aceturate. The silver and gold nanoparticles were synthesized, functionalized and coupled to diminazene aceturate following established protocols. The nanoparticle conjugates were characterized. The free diminazene aceturate and drug conjugated nanoparticles were subsequently evaluated for cytotoxicity in vitro. The characterizations by transmission electron microscopy or UV/Vis spectroscopy revealed that conjugation of diminazene aceturate to silver or gold nanoparticles was successful. Evaluation for cytotoxic actions in vitro demonstrated no significance difference between free diminazene aceturate and the conjugates. Our data suggest that surface modified metal nanoparticles could be optimized for drug delivery systems.
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    3. Wierzbicki M, Kot M, Lange A, et al. Evaluation of the Antimicrobial, Cytotoxic, and Physical Properties of Selected Nano-Complexes in Bovine Udder Inflammatory Pathogen Control. Nanotechnol Sci Appl, 2024, 17: 77-94. DOI:10.2147/NSA.S447810
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    7. Ullah A, Yin X, Wang F, et al. Biosynthesis of Selenium Nanoparticles (via Bacillus subtilis BSN313), and Their Isolation, Characterization, and Bioactivities. Molecules, 2021, 26(18): 5559. DOI:10.3390/molecules26185559
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    9. Costa IN, Ribeiro M, Silva Franco P, et al. Biogenic Silver Nanoparticles Can Control Toxoplasma gondii Infection in Both Human Trophoblast Cells and Villous Explants. Front Microbiol, 2021, 11: 623947. DOI:10.3389/fmicb.2020.623947
    10. Farghaly DS, Sadek AM. Trypanocidal activity of methanol extracts of the hemolymph of Sarcophaga argyrostoma larva against Trypanosoma evansi infected mice. Vet World, 2020, 13(8): 1599-1604. DOI:10.14202/vetworld.2020.1599-1604
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    12. Marcu IC, Eberhard N, Yerly A, et al. Isolation of Human Small Extracellular Vesicles and Tracking of their Uptake by Retinal Pigment Epithelial Cells In Vitro. Int J Mol Sci, 2020, 21(11): 3799. DOI:10.3390/ijms21113799
    13. Ebadi M, Saifullah B, Buskaran K, et al. Synthesis and properties of magnetic nanotheranostics coated with polyethylene glycol/5-fluorouracil/layered double hydroxide. Int J Nanomedicine, 2019, 14: 6661-6678. DOI:10.2147/IJN.S214923
    14. Alajmi RA, Al-Megrin WA, Metwally D, et al. Anti-Toxoplasma activity of silver nanoparticles green synthesized with Phoenix dactylifera and Ziziphus spina-christi extracts which inhibits inflammation through liver regulation of cytokines in Balb/c mice. Biosci Rep, 2019, 39(5): BSR20190379. DOI:10.1042/BSR20190379. Print 2019 May 31
    15. Baganizi DR, Nyairo E, Duncan SA, et al. Interleukin-10 Conjugation to Carboxylated PVP-Coated Silver Nanoparticles for Improved Stability and Therapeutic Efficacy. Nanomaterials (Basel), 2017, 7(7): 165. DOI:10.3390/nano7070165
    16. Das B, Tripathy S, Adhikary J, et al. Surface modification minimizes the toxicity of silver nanoparticles: an in vitro and in vivo study. J Biol Inorg Chem, 2017, 22(6): 893-918. DOI:10.1007/s00775-017-1468-x
    17. Hemmaragala NM, Abrahamse H, George BP. Effect of GNP functionalisation and multiple N-methylation of β-amyloid residue (32-37) on Gram-positive bacterium. IET Nanobiotechnol, 2017, 11(4): 377-382. DOI:10.1049/iet-nbt.2016.0083
    18. Adeyemi OS, Murata Y, Sugi T, et al. Inorganic nanoparticles kill Toxoplasma gondii via changes in redox status and mitochondrial membrane potential. Int J Nanomedicine, 2017, 12: 1647-1661. DOI:10.2147/IJN.S122178
    19. Bano S, Nazir S, Munir S, et al. "Smart" nickel oxide based core-shell nanoparticles for combined chemo and photodynamic cancer therapy. Int J Nanomedicine, 2016, 11: 3159-66. DOI:10.2147/IJN.S106533

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