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  • ISSN 1674-8301
  • CN 32-1810/R
Volume 26 Issue 6
Oct.  2012
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Abstract
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Ping Wang, Satoru Naruse, Hong Yin, Zhongfang Yu, Tianqu Zhuang, Wei Ding, Yanmin Wu, Muxin Wei. The susceptibility of T5-TG12 of the CFTR gene in chronic bronchitis occurrence in a Chinese population in Jiangsu province, China[J]. The Journal of Biomedical Research, 2012, 26(6): 410-417. DOI: 10.7555/JBR.26.20120015
Citation: Ping Wang, Satoru Naruse, Hong Yin, Zhongfang Yu, Tianqu Zhuang, Wei Ding, Yanmin Wu, Muxin Wei. The susceptibility of T5-TG12 of the CFTR gene in chronic bronchitis occurrence in a Chinese population in Jiangsu province, China[J]. The Journal of Biomedical Research, 2012, 26(6): 410-417. DOI: 10.7555/JBR.26.20120015
shu

The susceptibility of T5-TG12 of the CFTR gene in chronic bronchitis occurrence in a Chinese population in Jiangsu province, China

  • 1.

    Department of Traditional Chinese Medicine, the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China

  • 2.

    Department of Internal Medicine, the Miyoshi -City Hospital, Nagoya 466 -8550, Japan

  • 3.

    Department of Internal Medicine, the Affiliated Yangzhou Hospital, Traditional Chinese Medicine of the Nanjing University of Chinese Medicine, Yangzhou, Jiangsu 225009, China

  • 4.

    Department of Paediatrics, Yixing Hospital, Traditional Chinese Medicine, Yixing, Jiangsu 214200, China

  • 5.

    Department of Andrology, the Affiliated Suzhou Hospital, Traditional Chinese Medicine of the Nanjing University of Chinese Medicine, Suzhou, Jiangsu 215003, China

Funds: 

the Key Talent's Subsidy Project in Science and Education of the Jiangsu Province (No. 2007158)

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  • Received Date: February 21, 2012
    Graphical Abstract
    • Abstract
  • Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene have been implicated in the onset of cystic fibrosis and other clinical respiratory disorders. In the present study, we investigated the role of CFTR variations, poly-T, TG-repeats, and M470V in susceptibility to bronchial asthma and chronic bronchitis in a Chinese population in Jiangsu province, China. A total of 72 bronchial asthma patients, 68 chronic bronchitis pa-tients, and 117 healthy subjects were included in this study. The Tn-TGm haplotype was sequenced and the CFTR variant M470V was detected using restriction fragment length polymorphism (RFLP). We found that the fre-quency of T5-TG12-V470 in chronic bronchitis patients was 0.07%, which was notably higher than that in healthy subjects (0.01%) and bronchial asthma patients (0.04%). Thus, the presence of the T5-TG12 haplotype of the CFTR gene is likely to play a role in the development and progression of respiratory conditions, such as chronic bronchitis.
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