The?effects?of?diltiazem?in?renal?transplantation?patients?treated?with?cyclosporine?A

Wujun?Xue; Yong?Song; Puxun?Tian; Xiaoming?Ding; Xiaoming?Pan; Hang?Yan; Jun?Hou; Xinshun?Feng; Heli?Xiang; Xiaohui?Tian

doi:10.1016/S1674-8301(10)60044-9

Wujun?Xue, Yong?Song, Puxun?Tian, Xiaoming?Ding, Xiaoming?Pan, Hang?Yan, Jun?Hou, Xinshun?Feng, Heli?Xiang, Xiaohui?Tian. The?effects?of?diltiazem?in?renal?transplantation?patients?treated?with?cyclosporine?A[J]. The Journal of Biomedical Research, 2010, 24(4): 317-323. DOI: 10.1016/S1674-8301(10)60044-9

Citation:

The?effects?of?diltiazem?in?renal?transplantation?patients?treated?with?cyclosporine?A

Graphical Abstract

Graphical Abstract

Abstract

Abstract

Objective:?To?investigate?the?effects?of?diltiazem?and?cyclosporine?A?(CsA)?combination?therapy?on?protecting?the?kidney,?promoting?graft?functioning?and?improving?post-transplanted?kidney?recovery.?Methods:?The?blood?con-centrations?of?CsA,?the?condition?of?the?post-transplant?kidney,?the?rate?of?acute?rejection?(AR),?as?well?as?hepatic?and?renal?toxicity?in?636?cases?of?renal?transplant?recipients?were?determined?after?being?treated?by?CsA,?with?or?without?diltiazem.?Results:?Compared?with?the?control?group?which?received?CsA,?mycophenolate?mofetil?(MMF)?and?prednisolone?(Pred)?but?lacked?diltiazem,?the?group?receiving?these?agents?together?with?diltiazem?required?reduced?dosage?of?CsA?(P?