The?effects?of?diltiazem?in?renal?transplantation?patients?treated?with?cyclosporine?A

Objective:?To?investigate?the?effects?of?diltiazem?and?cyclosporine?A?(CsA)?combination?therapy?on?protecting?the?kidney,?promoting?graft?functioning?and?improving?post-transplanted?kidney?recovery.?Methods:?The?blood?con-centrations?of?CsA,?the?condition?of?the?post-transplant?kidney,?the?rate?of?acute?rejection?(AR),?as?well?as?hepatic?and?renal?toxicity?in?636?cases?of?renal?transplant?recipients?were?determined?after?being?treated?by?CsA,?with?or?without?diltiazem.?Results:?Compared?with?the?control?group?which?received?CsA,?mycophenolate?mofetil?(MMF)?and?prednisolone?(Pred)?but?lacked?diltiazem,?the?group?receiving?these?agents?together?with?diltiazem?required?reduced?dosage?of?CsA?(P?