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  • ISSN 1674-8301
  • CN 32-1810/R
Volume 24 Issue 4
Jun.  2010
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Article Contents
Abstract
Wujun?Xue, Yong?Song, Puxun?Tian, Xiaoming?Ding, Xiaoming?Pan, Hang?Yan, Jun?Hou, Xinshun?Feng, Heli?Xiang, Xiaohui?Tian. The?effects?of?diltiazem?in?renal?transplantation?patients?treated?with?cyclosporine?A[J]. The Journal of Biomedical Research, 2010, 24(4): 317-323. DOI: 10.1016/S1674-8301(10)60044-9
Citation: Wujun?Xue, Yong?Song, Puxun?Tian, Xiaoming?Ding, Xiaoming?Pan, Hang?Yan, Jun?Hou, Xinshun?Feng, Heli?Xiang, Xiaohui?Tian. The?effects?of?diltiazem?in?renal?transplantation?patients?treated?with?cyclosporine?A[J]. The Journal of Biomedical Research, 2010, 24(4): 317-323. DOI: 10.1016/S1674-8301(10)60044-9
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The?effects?of?diltiazem?in?renal?transplantation?patients?treated?with?cyclosporine?A

  • Department?of?Renal?Transplant,?Center?of?Nephropathy,?the?First?Affiliated?Hospital?of?Xi'an?Jiaotong?University,??Xi'an?710061,?Shaanxi?Province,?China

Funds: 

This?study?was?supported?by?the?"13115"?Innovation?Technology?Project?of?Special?Purpose?of?Shaanxi?Province(No.?2087ZDKG-67),?the?National?Natural?Science?Foundation?of?China?(No.?30772096),?the?Natural?Science?Foundation?of?Shaanxi?Province?(No.?2007C2C

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  • Received Date: November 16, 2009
    Graphical Abstract
    • Abstract
  • Objective:?To?investigate?the?effects?of?diltiazem?and?cyclosporine?A?(CsA)?combination?therapy?on?protecting?the?kidney,?promoting?graft?functioning?and?improving?post-transplanted?kidney?recovery.?Methods:?The?blood?con-centrations?of?CsA,?the?condition?of?the?post-transplant?kidney,?the?rate?of?acute?rejection?(AR),?as?well?as?hepatic?and?renal?toxicity?in?636?cases?of?renal?transplant?recipients?were?determined?after?being?treated?by?CsA,?with?or?without?diltiazem.?Results:?Compared?with?the?control?group?which?received?CsA,?mycophenolate?mofetil?(MMF)?and?prednisolone?(Pred)?but?lacked?diltiazem,?the?group?receiving?these?agents?together?with?diltiazem?required?reduced?dosage?of?CsA?(P?
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