4.6

CiteScore

2.2

Impact Factor
  • ISSN 1674-8301
  • CN 32-1810/R
Yuxuan Zhou, Yuan Yuan, Juan Gao, Ling Yang, Feng Zhang, Guoqing Zhu, Xingya Gao. An Implanted Closed-loop Chip System for Heart Rate Control: System Design and Effects in Conscious Rats[J]. The Journal of Biomedical Research, 2010, 24(2): 107-114. DOI: 10.1016/S1674-8301(10)60018-8
Citation: Yuxuan Zhou, Yuan Yuan, Juan Gao, Ling Yang, Feng Zhang, Guoqing Zhu, Xingya Gao. An Implanted Closed-loop Chip System for Heart Rate Control: System Design and Effects in Conscious Rats[J]. The Journal of Biomedical Research, 2010, 24(2): 107-114. DOI: 10.1016/S1674-8301(10)60018-8

An Implanted Closed-loop Chip System for Heart Rate Control: System Design and Effects in Conscious Rats

More Information
  • Objective: To evaluate the efficiency of an implanted chip system for the control of heart rate (HR). Methods: The HR was recorded in six conscious Sprague-Dawley (SD) rats. An implanted chip system was designed to regulate the HR by stimulating the right cervical vagus nerve according to the feedback of real time HR. Each rat was subjected to 30-min regulation and 30-min recovery. The change of HR during the regulation period was compared with the control. The ECG was recorded during the experiment for 24 h. Results: The ECG signals were successfully recorded during the experiment. The HR was significantly decreased during the period of regulation compared with control (-79.3 ± 34.5, P < 0.01, n = 6) and then recovered to normal after regulation. Conclusion: The described implanted chip system can regulate the HR to a designated set point.
  • Related Articles

    [1]Kaibo Lin, Shikun Zhang, Jieli Chen, Ding Yang, Mengyi Zhu, Eugene Yujun Xu. Generation and functional characterization of a conditional Pumilio2 null allele[J]. The Journal of Biomedical Research, 2018, 32(6): 434-441. DOI: 10.7555/JBR.32.20170117
    [2]Fengzhen Wang, Mingwan Zhang, Dongsheng Zhang, Yuan Huang, Li Chen, Sunmin Jiang, Kun Shi, Rui Li. Preparation, optimization, and characterization of chitosancoated solid lipid nanoparticles for ocular drug delivery[J]. The Journal of Biomedical Research, 2018, 32(6): 411-423. DOI: 10.7555/JBR.32.20160170
    [3]Christopher J. Danford, Zemin Yao, Z. Gordon Jiang. Non-alcoholic fatty liver disease: a narrative review of genetics[J]. The Journal of Biomedical Research, 2018, 32(6): 389-400. DOI: 10.7555/JBR.32.20180045
    [4]Kieran Walsh. Cost and value in medical education: the role of statistical process control[J]. The Journal of Biomedical Research, 2017, 31(4): 277-278. DOI: 10.7555/JBR.31.20160086
    [5]Jiawei Liao, Wei Huang, George Liu. Animal models of coronary heart disease[J]. The Journal of Biomedical Research, 2017, 31(1): 3-10. DOI: 10.7555/JBR.30.20150051
    [6]Di Zhao, Ze-Mu Wang, Lian-Sheng Wang. Prevention of atrial fibrillation with renin-angiotensin system inhibitors on essential hypertensive patients: a meta-analysis of randomized controlled trials[J]. The Journal of Biomedical Research, 2015, 29(6): 475-485. DOI: 10.7555/JBR.29.20140149
    [7]Gouri Sankar Bhunia, Manas Ranjan Dikhit, Shreekant Kesari, Ganesh Chandra Sahoo, Pradeep Das. Corrigendum to "Role of remote sensing, geographic bioinformatics system and bioinformatics in kala-azar epidemiology"[J]. The Journal of Biomedical Research, 2012, 26(5): 371-371. DOI: 10.1016/S1674-8301(11)60050-X]
    [8]Gouri Sankar Bhunia, Manas Ranjan Dikhit, Shreekant Kesari, Ganesh Chandra Sahoo, Pradeep Das. Role of remote sensing, geographic bioinformatics system and bioinformatics in kala-azar epidemiology[J]. The Journal of Biomedical Research, 2011, 25(6): 373-384. DOI: 10.1016/S1674-8301(11)60050-X
    [9]Hao Zhang, Hongyan Dong, Bo Jiang, Zheng Wang, Rui Chen, Zhifeng Zhang, Zhongming Zhang. Hypoxic response elements and Tet-On advanced double-controlled systems regulate hVEGF165 and angiopoietin-1 gene expression in vitro[J]. The Journal of Biomedical Research, 2011, 25(3): 204-212. DOI: 10.1016/S1674-8301(11)60027-4
    [10]Zhigang He. Intrinsic control of axon regeneration[J]. The Journal of Biomedical Research, 2010, 24(1): 2-5.

Catalog

    Article Metrics

    Article views (3254) PDF downloads (1625) Cited by()
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return