• ISSN 1674-8301
  • CN 32-1810/R
Volume 30 Issue 4
Jul.  2016
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Yu Fang, Zou Xiang. Roles and relevance of mast cells in infection and vaccination[J]. The Journal of Biomedical Research, 2016, 30(4): 253-263. doi: 10.7555/JBR.30.20150038
Citation: Yu Fang, Zou Xiang. Roles and relevance of mast cells in infection and vaccination[J]. The Journal of Biomedical Research, 2016, 30(4): 253-263. doi: 10.7555/JBR.30.20150038

Roles and relevance of mast cells in infection and vaccination

doi: 10.7555/JBR.30.20150038
Funds:

This work was supported by Stiftelsen Clas Groschinskys Minnesfond

Konsul Berghs Stiftelse, Sweden. YF was supported by a postdoctoral start-up grant from the Affiliated Hospital of Guizhou Medical University, Guiyang, China.

  • Received: 2015-02-26
  • Revised: 2015-04-08
  • Issue Date: 2016-07-28
  • In addition to their well-established role in allergy mast cells have been described as contributing to functional regulation of both innate and adaptive immune responses in host defense. Mast cells are of hematopoietic origin but typically complete their differentiation in tissues where they express immune regulatory functions by releasing diverse mediators and cytokines. Mast cells are abundant at mucosal tissues which are portals of entry for common infectious agents in addition to allergens. Here, we review the current understanding of the participation of mast cells in defense against infection. We also discuss possibilities of exploiting mast cell activation to provide adequate adjuvant activity that is needed in high-quality vaccination against infectious diseases.

     

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