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Solomon E. Owumi, Uche O. Arunsi, Moses T. Otunla, Imisioluwa O. Oluwasuji. Exposure to lead and dietary furan intake aggravates hypothalamus-pituitary-testicular axis toxicity in chronic experimental rats[J]. The Journal of Biomedical Research. doi: 10.7555/JBR.36.20220108F
Citation: Solomon E. Owumi, Uche O. Arunsi, Moses T. Otunla, Imisioluwa O. Oluwasuji. Exposure to lead and dietary furan intake aggravates hypothalamus-pituitary-testicular axis toxicity in chronic experimental rats[J]. The Journal of Biomedical Research. doi: 10.7555/JBR.36.20220108F

Exposure to lead and dietary furan intake aggravates hypothalamus-pituitary-testicular axis toxicity in chronic experimental rats

doi: 10.7555/JBR.36.20220108F
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  • Corresponding author: Solomon E. Owumi, ChangeLab, Changing Live, Room NB 302, Cancer Research and Molecular Biology Laboratories, Department of Biochemistry, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Oyo State 200004, Nigeria. Tel: +234-806-951-3033. E-mail: owumisa@hotmail.com
  • Received: 2022-05-11
  • Revised: 2022-06-18
  • Accepted: 2022-08-04
  • Published: 2022-09-28
  • Lead (Pb) and furan are toxic agents, and persistent exposure to humans and animals may impair reproductive function. We therefore explored the effect of Pb and furan on male rat hypothalamic-pituitary-gonadal reproductive status, oxidative stress, inflammation, and genomic integrity. We found that co-exposure to Pb and furan reduced the activities of testicular function enzymes and endogenous antioxidant levels, total sulfhydryl group, and glutathione. Sperm abnormality, biomarkers of oxidative stress, inflammation, and p53 expression were increased in dose-dependent manner by treatment with furan and Pb. Typical rat gonad histoarchitecture features were also damaged. Convincingly, co-exposure to furan—a steroid hormone disruptor; and lead—a toxic metal common in water pipes—induced male reproductive function derangement by decreasing the antioxidant defences in rats, increasing abnormalities in spermatozoa morphology, and reducing reproductive hormone in circulation. These pathophysiological alterations, if persistent, might provide a permissive environment for potentiating reproductive dysfunction and infertility.

     

  • CLC number: X592; R114, Document code: A
    The authors reported no conflict of interests.
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